Regulation of membrane transport through the endocytic pathway by rabGTPases.
Regulation of membrane transport through the endocytic pathway by rabGTPases.
复制标题
DOI：
10.1080/096876899294797
复制
发表时间：
1999
影响因子：
--
通讯作者：
K. Mohrmann;P. Sluijs
中科院分区：
文献类型：
--
作者：
K. Mohrmann;P. Sluijs
rab家族的小GTP结合蛋白与中央液泡系统的隔室的细胞质表面相关。其中几个，包括rab5，rab4和rab11，定位于早期内吞细胞器，在那里他们调节不同的事件转铁蛋白受体途径。rab5控制着向早期内体的转运，而rab4和rab11则参与调节再循环回到质膜。rab结合GTP的GTP水解如何与这些蛋白在内吞作用中的作用相关尚不清楚，但通过鉴定调节这些rab蛋白活性的蛋白质，正在朝着这一目标取得快速进展。
Small GTP binding proteins of the rab family are associated with the cytoplasmic surface of compartments of the central vacuolar system. Several of them, including rab5, rab4 and rab11, are localized to early endocytic organelles where they regulate distinct events in the transferrin receptor pathway. Whereas rab5 is controlling transport to early endosomes, rab4 and rab11 are involved in the regulation of recycling back to the plasma membrane. How GTP-hydrolysis of rab bound GTP is related to the role of these proteins in endocytosis is not yet known, but quick progress is being made towards this goal through the identification of proteins regulating the activity of these rab proteins.