Strong Evidence for Pattern Separation in Human Dentate Gyrus
Strong Evidence for Pattern Separation in Human Dentate Gyrus
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DOI：
10.1523/jneurosci.0518-16.2016
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发表时间：
2016-07-20
影响因子：
5.3
通讯作者：
Duezel, Emrah
中科院分区：
文献类型：
--
作者：
Berron, David;Schuetze, Hartmut;Duezel, Emrah
海马体被认为是通过执行模式分离计算来区分相似经历的关键，该计算为相关情节创建正交化表示。以往的神经影像研究间接证明，齿状回(DG)和CA3亚区通过观察新奇信号来推断潜在表征的性质，从而支持模式分离。在这里，我们使用7T的超高分辨率fMRI和多变量模式分析来提供令人信服的证据，证明DG分区特别支持与其他海马(例如CA3)和内侧颞叶区域(例如内嗅皮层)重叠较少的相似场景的表示。此外，我们提供的证据表明，DG中的新奇信号本质上是刺激特定的，而不是通用的。我们的研究在新奇信号和潜在表征之间提供了一种机械联系，这是人类DG执行模式分离的第一个证明。
The hippocampus is proposed to be critical in distinguishing between similar experiences by performing pattern separation computations that create orthogonalized representations for related episodes. Previous neuroimaging studies have provided indirect evidence that the dentate gyrus (DG) and CA3 hippocampal subregions support pattern separation by inferring the nature of underlying representations from the observation of novelty signals. Here, we use ultra-high-resolution fMRI at 7 T and multivariate pattern analysis to provide compelling evidence that the DG subregion specifically sustains representations of similar scenes that are less overlapping than in other hippocampal (e.g., CA3) and medial temporal lobe regions (e.g., entorhinal cortex). Further, we provide evidence that novelty signals within the DG are stimulus specific rather than generic in nature. Our study, in providing a mechanistic link between novelty signals and the underlying representations, constitutes the first demonstration that the human DG performs pattern separation.