Restoring emotional stability: Cortisol effects on the neural network of cognitive emotion regulation
Restoring emotional stability: Cortisol effects on the neural network of cognitive emotion regulation
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DOI：
10.1016/j.bbr.2019.03.049
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发表时间：
2019-11-18
影响因子：
2.7
通讯作者：
Wolf, Oliver T.
中科院分区：
文献类型：
--
作者：
Jentsch, Valerie L.;Merz, Christian J.;Wolf, Oliver T.
在压力环境中有效的情绪调节是心理健康的一个重要特征。然而，严重的压力会损害前额叶自上而下的控制，可能会导致情绪调节能力的下降。相比之下，应激源或药物操作后皮质醇的延迟增加与情绪保护效果和情绪调节成功有关。在这项功能磁共振成像研究中，健康的男性和女性在接触到中性和负面图片的情绪调节范例之前90分钟，服用了30毫克皮质醇或安慰剂。正如预期的那样，行为和大脑成像数据表明，通过认知重新评估和分心，成功地诱导和抑制了负面情绪。当参与者使用分心技术时，皮质醇增强了腹外侧额叶皮质的调节活性，而当通过认知重新评估来调节情绪时，杏仁核中与情绪相关的激活减少。总之，这些发现为糖皮质激素诱导的认知情绪调节过程的延迟促进提供了第一个证据，这可能有助于在应激事件后恢复情绪稳定。
Effective emotion regulation in stressful contexts is a key feature of mental health. Acute stress, however, impairs prefrontal top-down control, probably leading to a decline of emotion regulatory capacities. By contrast, the delayed cortisol increase in response to a stressor or after a pharmacological manipulation has been linked to mood-protecting effects and emotion regulation success. In this functional magnetic resonance imaging study, healthy men and women received either 30 mg cortisol or placebo 90 min before they were exposed to an emotion regulation paradigm involving neutral and negative pictures. As expected, behavioural and brain imaging data indicated successful induction and downregulation of negative emotions via cognitive reappraisal and distraction. Cortisol enhanced regulatory activity in the ventrolateral prefrontal cortex when participants used distraction and reduced emotion-related activation in the amygdala when regulating emotions via cognitive reappraisal. Together, these findings provide first evidence for a delayed glucocorticoid-induced facilitation of cognitive emotion regulation processes that might be beneficial for restoring emotional stability in the aftermath of stressful events.