Seroepidemiology of human T-lymphotropic virus type III among homosexual men with the acquired immunodeficiency syndrome or generalized lymphadenopathy and among asymptomatic controls in Boston.
Seroepidemiology of human T-lymphotropic virus type III among homosexual men with the acquired immunodeficiency syndrome or generalized lymphadenopathy and among asymptomatic controls in Boston.
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波士顿患有获得性免疫缺陷综合征或全身性淋巴结肿大的同性恋男性以及无症状对照者中人类 T 淋巴细胞病毒 III 型的血清流行病学。
DOI：
10.7326/0003-4819-102-3-334
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发表时间：
1985
影响因子：
39.2
通讯作者：
R. Gallo
中科院分区：
文献类型：
--
作者：
J. Groopman;K. Mayer;M. Sarngadharan;D. Ayotte;A. Devico;R. Finberg;A. Sliski;J. Allan;R. Gallo
我们研究了45名患有获得性免疫缺陷综合征的男同性恋者，78名患有持续不明原因的全身性淋巴结病的男性，以及160名无症状的同性恋对照者，以寻找感染人类t淋巴细胞性病毒III型（HTLV-III）的血清学证据。研究参与者是从社区卫生中心和大学医院招募的。98%的男性综合征患者和超过90%的男性全身性淋巴结病患者有HTLV-III抗体，而21%的对照组呈阳性（p < 0.001）。6例全身性淋巴结病患者在2年内发展为获得性免疫缺陷综合征；所有患者HTLV-III血清均呈阳性。36名无症状对照者曾与一名患有该综合征的男性发生过性接触；该组接受性肛交与HTLV-III血清阳性相关。这些数据表明，持续的全身性淋巴结病和获得性免疫缺陷综合征是HTLV-III感染的临床谱的一部分，美国一些地区的大多数高危同性恋男性尚未感染这种病毒。
We studied a cohort of 45 homosexual men with the acquired immunodeficiency syndrome, 78 with persistent unexplained generalized lymphadenopathy, and 160 asymptomatic homosexual controls for serologic evidence of infection with human T-lymphotropic virus type III (HTLV-III). Study participants were recruited from a community-based health center and a university hospital practice. Ninety-eight percent of men with the syndrome and greater than 90% of men with generalized lymphadenopathy had antibody to HTLV-III, while 21% of the controls were positive (p less than 0.001). Six patients with generalized lymphadenopathy developed the acquired immunodeficiency syndrome over 2 years; all were seropositive for HTLV-III. Thirty-six asymptomatic controls had had sexual contact with a man with the syndrome; receptive anal intercourse in this group was associated with seropositivity for HTLV-III. These data suggest that persistent generalized lymphadenopathy and the acquired immunodeficiency syndrome are part of a clinical spectrum of HTLV-III infection and that most high-risk homosexual men in some regions of the United States have not yet been infected with this virus.
影响因子：
158.5
作者：
KLEIN, RS;HARRIS, CA;FRIEDLAND, GH
通讯作者：
FRIEDLAND, GH