Epidemiology of cytokines: the Women On the Move through Activity and Nutrition (WOMAN) Study.
Epidemiology of cytokines: the Women On the Move through Activity and Nutrition (WOMAN) Study.
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细胞因子的流行病学：通过活动和营养进行活动的女性 (WOMAN) 研究。
DOI：
10.1093/aje/kwn132
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发表时间：
2008
影响因子：
5
通讯作者：
Kuller,Lewis
中科院分区：
文献类型：
--
作者：
Wong,Eric;Freiberg,Matthew;Tracy,Russell;Kuller,Lewis
使用多重技术，作者研究了一组细胞因子（白细胞介素（IL）-1a，IL-1受体拮抗剂，IL-4，IL-6，IL-8，IL-10，干扰素诱导蛋白-10，单核细胞趋化蛋白-1和肿瘤坏死因子-α）在18个月内的实验室和生物学变化及其与心血管疾病风险因素，激素治疗和体重减轻的关系。数据来自于女性活动和营养研究（WOMAN），这是一项随机临床试验，旨在研究非药物干预对宾夕法尼亚州超重绝经后女性亚临床动脉粥样硬化的影响。目前的分析（2002年2月至2005年8月）包括290名年龄在52-62岁（平均年龄= 57岁）的妇女。大多数细胞因子在大多数样本中可检测到，个体间生物学变异大于个体内生物学和实验室变异。基线时使用激素治疗或18个月时改变激素治疗与细胞因子水平之间几乎没有关联。体重减轻与IL-1受体拮抗剂、IL-6和C反应蛋白水平降低相关。结果表明，可以从一个样品同时测量宽面板的细胞因子。细胞因子水平存在很大的无法解释的变异性，这可能是由于遗传-环境相关性。
Using multiplex technology, the authors investigated the laboratory and biologic variation of a panel of cytokines (interleukin (IL)-1a, IL-1 receptor antagonist, IL-4, IL-6, IL-8, IL-10, interferon-inducible protein-10, monocyte chemoattractant protein-1, and tumor necrosis factor-α) over 18 months and their relations to cardiovascular disease risk factors, hormone therapy, and weight loss. Data were obtained from the Woman On the Move through Activity and Nutrition (WOMAN) Study, a randomized clinical trial investigating the effect of nonpharmacologic interventions on subclinical atherosclerosis among overweight, postmenopausal women in Pennsylvania. The present analysis (February 2002–August 2005) comprised 290 women aged 52–62 years (mean age = 57 years). Most of the cytokines were detectable in a majority of the samples, and the between-individual biologic variation was greater than the within-individual biologic and laboratory variation. There was little association between use of hormone therapy at baseline or change in hormone therapy by 18 months and cytokine levels. Weight loss was associated with a decrease in levels of IL-1 receptor antagonist, IL-6, and C-reactive protein. The results suggest that a wide panel of cytokines may be measured simultaneously from one sample. There is large unexplained variability in cytokine levels that is probably due to genetic-environmental associations.