ECM signalling: orchestrating cell behaviour and misbehaviour
ECM signalling: orchestrating cell behaviour and misbehaviour
复制标题
DOI：
10.1016/s0962-8924(98)01362-2
复制
发表时间：
1998-11-01
影响因子：
19
通讯作者：
Werb, Z
中科院分区：
文献类型：
--
作者：
Lukashev, ME;Werb, Z
细胞外基质（ECM）提供信号信号，调节细胞行为，协调细胞在组织形成和体内平衡中的功能。ECM的组成，其三维组织和蛋白水解重塑是主要决定因素；近年来，有证据表明，细胞-ECM相互作用的错误调节可能导致许多疾病，包括发育、免疫、血流停滞、退行性和恶性疾病，从而强调了ECM信号传导的重要性。这篇综述讨论了最近对ECM的调节功能及其在疾病中的作用的见解，重点是作为范例的癌症。
The extracellular matrix (ECM) provides signalling cues that regulate cell behaviour and orchestrate functions of cells in tissue formation and homeostasis. The composition of the ECM, its three-dimensional organization and proteolytic remodelling are major determinants; of the microenvironmental signalling context that controls cell shape, motility, growth, survival and differentiation, In recent years, the importance of ECM signalling has been underscored by the evidence that misregulation of cell-ECM interactions can contribute to many diseases, including developmental, immune, haemostasis, degenerative and malignant disorders. This review discusses recent insights into the regulatory functions of the ECM and their role in disease, focusing on cancer as a paradigm.