Acoustic prepulse inhibition in male and female prairie voles: Implications for models of neuropsychiatric illness.
Acoustic prepulse inhibition in male and female prairie voles: Implications for models of neuropsychiatric illness.
复制标题
雄性和雌性草原田鼠的声学前脉冲抑制：对神经精神疾病模型的影响。
DOI：
10.1016/j.bbr.2018.12.022
复制
发表时间：
2019
影响因子：
2.7
通讯作者：
Lim,MirandaM
中科院分区：
文献类型：
--
作者：
Jones,CarolynE;Navis,TomM;Teutsch,Peyton;Opel,RyanA;Lim,MirandaM
Sensory gating, the ability to suppress sensory information of irrelevant stimuli, is affected in several neuropsychiatric diseases, notably schizophrenia and autism. It is currently unclear how these deficits interact with other hallmark symptoms of these disorders, such as social withdrawal and difficulty with interpersonal relationships. The highly affiliative prairie vole(Microtus ochrogaster)may be an ideal model organism to study the neurobiology underlying social behavior. In this study, we assessed unimodal acoustic sensory gating in male and female prairie voles using the prepulse inhibition (PPI) paradigm, whereby a lower amplitude sound (prepulse) decreases the startle response to a high amplitude sound (pulse) compared to the high amplitude sound alone. Prairie voles showed evidence of PPI at all prepulse levels compared to pulse alone, with both males and females showing similar levels of inhibition. However, unlike what has been reported in other rodent species, prairie voles did not show a within-session decrease in startle response to the pulse alone, nor did they show a decrease in startle response to the pulse over multiple days, highlighting their inability to habituate to startling stimuli (short- and long-term). When contrasted with a cohort of male wildtype C57Bl/6J mice that underwent a comparable PPI protocol, individual voles showed significantly higher trial-by-trial variability as well as longer latency to startle than mice. The benefits and caveats to using prairie voles in future sensory gating experiments are discussed.
