Stimulation of phosphatidic acid and phosphatidylinositol labeling in luteal cells by luteinizing hormone releasing hormone.
Stimulation of phosphatidic acid and phosphatidylinositol labeling in luteal cells by luteinizing hormone releasing hormone.
复制标题
黄体生成素释放激素刺激黄体细胞中的磷脂酸和磷脂酰肌醇标记。
DOI：
10.1210/endo-112-3-1138
复制
发表时间：
1983
期刊：
影响因子：
4.8
通讯作者：
F. Labrie
中科院分区：
文献类型：
--
作者：
P. Leung;V. Raymond;F. Labrie
黄体生成素释放激素（LHRH）导致培养的大鼠黄体细胞中[32P]正磷酸盐掺入磷脂酰肌醇（PI）和磷脂酸（PA）的量迅速显著增加。神经激素在ED50值约为15 nM时发挥其刺激作用。人绒毛膜促性腺激素（hCG）单独没有作用，也不会干扰lhrh诱导的PA-PI标记。LHRH作用的快速性和特异性表明，刺激PA-PI周期可能是LHRH及其激动剂在卵巢水平直接作用的有效转导机制。
Luteinizing hormone-releasing hormone (LHRH) causes a rapid and marked increase of [32P]orthophosphate incorporation into phosphatidylinositol (PI) and phosphatidic acid (PA) in rat luteal cells in culture. The neurohormone exerts its stimulatory effect at an ED50 value of approximately 15 nM. Human chorionic gonadotropin (hCG) has no effect alone and does not interfere with the LHRH-induced PA-PI labeling. The rapidity and the specificity of the effect of LHRH suggest that the stimulation of the PA-PI cycle may well serve as a potent transducing mechanism responsible for the direct action of LHRH and its agonists at the ovarian level.