Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy
Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy
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DOI：
10.1016/j.neuroimage.2004.03.051
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发表时间：
2004-08-01
期刊：
影响因子：
5.7
通讯作者：
Ahrens, ET
中科院分区：
文献类型：
--
作者：
Koshibu, K;Levitt, P;Ahrens, ET
大脑结构的两性异形在一些物种中已经被报道过。我们报道了C57 Bl/6（J）小鼠脑功能遗传分析的常见模型中存在的性别依赖性发育结构变化。在雄性和雌性成年小鼠和青春期小鼠的完整脑中获得高分辨率三维（31）磁共振显微镜（MRM）图像。对侧脑室、第三脑室、海马、杏仁核、纹状体和全脑进行三维重建。正如在人类中观察到的那样，两性从青春期到成年期都有整体的大脑生长。在校正了大脑体积的增加后，成年小鼠的海马体和杏仁核比青春期小鼠大得不成比例。还观察到几种两性异形。与男性相比，女性的侧脑室较大，而杏仁核（特别是左侧）较小。仅雄性动物的侧脑室和第三脑室随时间推移而缩小，表现出性别特异性发育特征。纹状体的大小是均匀的研究组之间。测定分段结构的表面积。基于表面积和体积测量之间缺乏协方差，检测到侧脑室、海马和整体脑结构的可能形状失真。虽然许多性二态性的变化报告围产期，我们的研究结果表明，有额外的性别特异性转换发生在青春期前后，并持续到成年期。(C)2004年爱思唯尔公司All rights reserved.
Sexual dimorphism of brain structures has been reported in some species. We report that sex-dependent developmental structure changes exist in the C57Bl/6(J) mouse, a common model for the genetic analysis of brain function. High resolution, three-dimensional (31)) magnetic resonance microscopy (MRM) images were obtained in intact brains of male and female adult and peripubertal mice. The lateral and third ventricles, hippocampus, amygdala, striation, and total brain were reconstructed in 3D. As observed in humans, there was overall cerebral growth from peripuberty to adulthood in both sexes. After correcting for the increased brain size, the hippocampus and amygdala were disproportionately larger in adult compared to peripubertal mice. Several sexual dimorphisms were also observed. The lateral ventricles were larger, while the amygdala (the left side in particular) was smaller in females compared to males. Lateral and third ventricles were reduced over time in males only, exhibiting a sex-specific developmental profile. The striatal size was uniform among the groups studied. The surface area of the segmented structures was assayed. Possible shape distortions were detected for the lateral ventricles, hippocampus, and overall brain structure based on a lack of covariance between the surface area and volumetric measurements. Although many sexually dimorphic changes are reported perinatally, our results suggest that there are additional sex-specific transformations that occur around puberty and persist in adulthood. (C) 2004 Elsevier Inc. All rights reserved.