TRANSMISSION THROUGH THE FEMALE LINE OF A MECHANISM CONSTRAINING HUMAN-FETAL GROWTH
TRANSMISSION THROUGH THE FEMALE LINE OF A MECHANISM CONSTRAINING HUMAN-FETAL GROWTH
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DOI：
10.1080/03014468600008281
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发表时间：
1986-03-01
影响因子：
1.7
通讯作者：
OUNSTED, C
中科院分区：
文献类型：
--
作者：
OUNSTED, M;SCOTT, A;OUNSTED, C
大型哺乳动物和小型哺乳动物之间的杂交实验表明，母体生物对胎儿生长的控制具有强大的影响力。母体调节因子的优势也已在人类中得到证实。我们早期的研究表明，这种调节器的行为方式的约束，没有等效的加速机制。对986名先证者的1092名兄弟姐妹和5207名父亲和母亲亲属的数据显示，通过非常大和非常小的婴儿分别确定的家庭中的出生体重的不同模式。当限制放松时，孟德尔遗传定律就被清楚地遵循了。在较低的极端有证据表明，通过女性线的传输约束。这可能是由于母亲的基因型，但我们的数据表明，一个非孟德尔路径也可能参与。这样的过程将是一种适应性的，随着人口生活条件的恶化或改善，促进胎儿生长速度的相当快的变化。
Cross-breeding experiments between large and small strains of mammals have shown the powerful influence of the maternal organism on the control of fetal growth. The prepotency of a maternal regulator has also been demonstrated in humans. Our earlier studies indicated that this regulator acts by means of constraint; there is no equivalent accelerating mechanism. Data on 1092 siblings and 5207 paternal and maternal relatives of 986 probands show different patterns of birthweight among families ascertained, respectively, through very large and very small babies. When constraint is relaxed the Mendelian laws of inheritance are clearly followed. At the lower extreme there is evidence for the transmission of constraint through the female line only. This could be due to the maternal genotype, but our data suggest that a non-Mendelian path might also be involved. Such a process would be a adaptive, facilitating fairly fast changes in fetal growth rate as the conditions under which a population lives deteriorate or improve.