Influenza Outbreaks during World Youth Day 2008 Mass Gathering
Influenza Outbreaks during World Youth Day 2008 Mass Gathering
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DOI：
10.3201/eid1605.091136
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发表时间：
2010-05-01
影响因子：
11.8
通讯作者：
Dwyer, Dominic E.
中科院分区：
文献类型：
--
作者：
Blyth, Christopher C.;Foo, Hong;Dwyer, Dominic E.
大规模集会期间的流感暴发很少被描述，也缺乏详细的病毒学评估。2008年7月在澳大利亚悉尼举行的世界青年节期间发生了流感疫情。我们评估了流行病学数据和呼吸道样本，这些样本是从这次疫情期间在悉尼急诊诊所寻求流感样疾病治疗的与会者中收集的。将分离的流感病毒与2008年流感季节的季节性流感病毒进行比较。从100名受感染的与会者中鉴定出许多毒株：奥司他韦耐药甲型流感（H1N1）病毒、奥司他韦敏感甲型流感（H1N1）病毒、甲型流感（H3 N2）病毒和来自两种B流感谱系（B/佛罗里达/4/2006样和B/Malaysia/2506/2004样）的毒株。引入了新的病毒，并扩增了2008年前的季节性病毒。在大规模集会中分离的病毒可能对社区流感活动产生重大、复杂和不可预测的影响。公共卫生当局和医院需要更大的灵活性，以适当管理和控制这些疫情。
Influenza outbreaks during mass gatherings have been rarely described, and detailed virologic assessment is lacking. An influenza outbreak occurred during World Youth Day in Sydney, Australia, July 2008 (WYD2008). We assessed epidemiologic data and respiratory samples collected from attendees who sought treatment for influenza-like illness at emergency clinics in Sydney during this outbreak. Isolated influenza viruses were compared with seasonal influenza viruses from the 2008 influenza season. From 100 infected attendees, numerous strains were identified: oseltamivir-resistant influenza A (H1N1) viruses, oseltamivir-sensitive influenza A (H1N1) viruses, influenza A (H3N2) viruses, and strains from both influenza B lineages (B/Florida/4/2006-like and B/Malaysia/2506/2004-like). Novel viruses were introduced, and pre-WYD2008 seasonal viruses were amplified. Viruses isolated at mass gatherings can have substantial, complex, and unpredictable effects on community influenza activity. Greater flexibility by public health authorities and hospitals is required to appropriately manage and contain these outbreaks.