Inhibitory control and negative emotional processing in psychopathy and antisocial personality disorder.
Inhibitory control and negative emotional processing in psychopathy and antisocial personality disorder.
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DOI：
10.1037/a0025308
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发表时间：
2012-01
影响因子：
4.6
通讯作者：
E. Verona;Jenessa Sprague;N. Sadeh
中科院分区：
文献类型：
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作者：
E. Verona;Jenessa Sprague;N. Sadeh
人格障碍领域长期以来一直有兴趣了解情绪和抑制性控制之间的相互作用，以及这些过程的神经生理学指标。尤其需要更多的工作来澄清在精神变态特征上不同的反社会人格障碍罪犯的区别缺陷，因为反社会人格障碍和精神变态被认为是独立的，尽管是相关的。这些障碍中不同神经生物学处理的证据将对未来精神病学分类系统中基于病因学的人格障碍分类产生影响。为了给这方面的研究提供信息，我们在情绪-语言GO/NO-GO任务中记录了事件相关脑电位，以检验三组负情绪加工的抑制控制的调节：精神病(n=14)、动作障碍(n=16)和对照组(n=15)。在控制型罪犯中，抑制性控制需求(不去与去)将额叶P3波幅调制为消极的情绪词，表明抑制适当优先于情绪处理。相比之下，精神病患者组对消极情绪词的加工迟钝，而不考虑抑制性控制需求，这与精神病患者中情绪缺陷的研究一致。最后，在GO和NO-GO实验中，apd组都展示了对负面情绪词的增强处理，这表明当需要抑制性控制时，未能调节负面情绪的处理。对这些人格障碍的情绪-认知交互作用和假定的病因过程的含义进行了讨论。
The field of personality disorders has had a long-standing interest in understanding interactions between emotion and inhibitory control, as well as neurophysiological indices of these processes. More work in particular is needed to clarify differential deficits in offenders with antisocial personality disorder (APD) who differ on psychopathic traits, as APD and psychopathy are considered separate, albeit related, syndromes. Evidence of distinct neurobiological processing in these disorders would have implications for etiology-based personality disorder taxonomies in future psychiatric classification systems. To inform this area of research, we recorded event-related brain potentials during an emotional-linguistic Go/No-Go task to examine modulation of negative emotional processing by inhibitory control in three groups: psychopathy (n = 14), APD (n = 16), and control (n = 15). In control offenders, inhibitory control demands (No-Go vs. Go) modulated frontal-P3 amplitude to negative emotional words, indicating appropriate prioritization of inhibition over emotional processing. In contrast, the psychopathic group showed blunted processing of negative emotional words regardless of inhibitory control demands, consistent with research on emotional deficits in psychopathy. Finally, the APD group demonstrated enhanced processing of negative emotion words in both Go and No-Go trials, suggesting a failure to modulate negative emotional processing when inhibitory control is required. Implications for emotion-cognition interactions and putative etiological processes in these personality disorders are discussed.