Phospholipase C-like protein 2 (PLC-L2) is associated with cytolytic ability of CD8(+) T cells and prognosis of prostate cancer
Phospholipase C-like protein 2 (PLC-L2) is associated with cytolytic ability of CD8(+) T cells and prognosis of prostate cancer
复制标题
磷脂酶 C 样蛋白 2 (PLC-L2) 与 CD8( ) T 细胞的细胞溶解能力和前列腺癌的预后相关
DOI：
10.1166/mex.2020.1694
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发表时间：
2020
影响因子：
0.7
通讯作者：
Huang Hai
中科院分区：
文献类型：
--
作者：
Li Kaiwen;Ma Xiaoming;Wang Qiong;Zhou Qianghua;Chen Xu;Guo Zhenghui;Lai Yiming;Tao Yiran;Wu Wanhua;Peng Shirong;Cai Wenli;Bai Shoumin;Huang Hai
PLC-L2 的相关家族成员促进 T 细胞的分化，是 PCa 的潜在表观遗传标记。 PCa 中肿瘤浸润 CD8+ T 细胞的密度与更好的预后相关。目前尚不清楚 PLC-L2 如何影响 TIL 和 PCa。使用人体组织微阵列 (TMA) 和癌症基因组图谱中的 PCa 患者来研究 PLC-L2 与浸润的免疫细胞之间的相关性，并评估 PLC-L2 与 PCa 患者预后之间的关系。就病理分级、临床分期以及是否存在淋巴结和远处转移而言，较晚期的 PCa 表达的 PLC-L2 较较不晚期的 PCa 少。此外，PLC-L2的表达与CD8+T细胞以及巨噬细胞、树突状细胞等抗原呈递细胞呈正相关。 PLC-L2表达还与局部免疫溶细胞能力、TNF-α、IFN-γ、IL-12A、IL-12B和IL-18呈正相关。此外，PLC-L2 表达是 PCa 患者预后良好的独立因素。这项研究表明，PLC-L2 可能会招募 CD8+ T 细胞并促进其在 PCa 中的细胞溶解能力。 PLC-L2 联合 CD8+ 细胞毒性 T 细胞可以抑制 PCa 的发展，从而改善 PCa 患者的预后。
PLC-L2, whose related members of its family facilitate in the differentiation of T cells, is a potential epigenetic marker for PCa. The density of tumor-infiltrating CD8+ T cells in PCa is associated with a better prognosis. It remains unclear how PLC-L2 affects the TIL and PCa. A human tissue microarray (TMA) and PCa patients from the Cancer Genome Atlas were used to address the correlations between PLC-L2 and the infiltrated immune cells and to evaluate the relationship between PLC-L2 and prognosis of PCa patients. More advanced PCa expressed less PLC-L2 than less advanced PCa, in terms of pathological grade, clinical stage, and the presence of lymph node and distant metastasis. Besides, the expression of PLC-L2 had positive correlations with CD8+ T cells and antigen-presenting cells such as macrophage and dendritic cells. PLC-L2 expression was also positively correlated with local immune cytolytic ability, TNF-alpha, IFN-gamma, IL-12A, IL-12B, and IL-18. Furthermore, PLC-L2 expression was an independent factor of a favorable prognosis in PCa patients. This study reveals that PLC-L2 might recruit CD8+ T cells and promote their cytolytic ability in PCa. PLC-L2 accompanied by CD8+ cytotoxic T cells could suppress the development of PCa and subsequently increase prognosis in PCa patients.