Comparison of corneal epithelial cellular growth on synthetic cornea materials.
Comparison of corneal epithelial cellular growth on synthetic cornea materials.
复制标题
合成角膜材料上角膜上皮细胞生长的比较。
DOI：
10.1016/s0142-9612(01)00257-5
复制
发表时间：
2002
期刊：
影响因子：
14
通讯作者：
Pitt,WilliamG
中科院分区：
文献类型：
--
作者：
George,Andrew;Pitt,WilliamG
人工角膜在眼表严重创伤中的应用一直面临着与角膜上皮细胞的生物相容性问题。为了使眼睛保持健康，它必须在人工角膜表面上持续拥有完整的CEC。已经检查了不同聚合物材料的各种表面改性，以确定哪些具有最佳的细胞生长速率。基于线性有丝分裂生长速率，建立了角膜细胞在合成材料上生长曲线的数学模型。使用该模型分析了CEC在改性聚乙烯醇、硅橡胶、聚苯乙烯和聚碳酸酯上生长的实验数据，以估计线性有丝分裂速率常数（k）。该模型被证明是有用的比较数据从不同的调查。等离子体诱导的接枝共聚聚（甲基丙烯酸羟乙酯）（pHEMA）的硅橡胶提供了最好的增长率，从这个特定的数据集。
The application of artificial corneas for severely wounded ocular surfaces has always encountered the problem of biocompatibility with corneal epithelial cells (CECs). For the eye to stay healthy, it must continually have a complete sheet of CECs across the artificial corneal surface. Various surface modifications of different polymeric materials have been examined to determine which have the best cellular growth rates. A mathematical model of corneal cell growth profiles on synthetic materials was formulated based upon a linear mitotic growth rate. Experimental data reported for the CEC growth on modified poly(vinyl alcohol), silicone rubber, polystyrene, and polycarbonate was analyzed using the model to estimate the linear mitotic rate constant (k). The model proved to be useful in comparing data from different investigators. Plasma-induced graft copolymerized poly(hydroxyethyl methacrylate) (pHEMA) on silicone rubber provided the best growth rate from this particular set of data.