Fractal Analysis of Dynamic Stress CT-Perfusion Imaging for Detection of Hemodynamically Relevant Coronary Artery Disease
Fractal Analysis of Dynamic Stress CT-Perfusion Imaging for Detection of Hemodynamically Relevant Coronary Artery Disease
复制标题
动态负荷CT灌注成像检测血流动力学相关冠状动脉病变的分形分析
DOI：
10.1016/j.jcmg.2022.03.015
复制
发表时间：
2022-09-01
影响因子：
14
通讯作者：
Kitagawa, Kakuya
中科院分区：
文献类型：
--
作者：
Michallek, Florian;Nakamura, Satoshi;Kitagawa, Kakuya
联合计算机断层扫描心肌血流量（CTP-MBF）和计算机断层扫描血管造影（CTA）已显示出良好的诊断性能，用于检测冠状动脉疾病（CAD）。然而，分形分析可能通过表征多尺度灌注模式来提供对缺血病理生理学的额外了解，并且因此可能在诊断血流动力学显著CAD中是有用的。结论本研究的目的是在多中心环境中调查灌注的分形分析是否使用动态、4维、动态应力心肌计算机断层扫描灌注（CTP）成像方法总共有7个中心参与了前瞻性AMPLIFIED（用双源CT探索的与梗死和纤维化相关的心肌灌注评估）研究，在疑似或已知CAD的患者中采集CTP和CTA数据。血流动力学相关CAD定义为有创冠状动脉造影或血流储备分数显示狭窄≥ 90%
BACKGROUND Combined computed tomography-derived myocardial blood flow (CTP-MBF) and computed tomography angiography (CTA) has shown good diagnostic performance for detection of coronary artery disease (CAD). However, fractal analysis might provide additional insight into ischemia pathophysiotogy by characterizing multiscale perfusion patterns and, therefore, may be useful in diagnosing hemodynamically significant CAD.OBJECTIVES The purpose of this study was to investigate, in a multicenter setting, whether fractal analysis of perfusion improves detection of hemodynamically relevant CAD over myocardial blood flow quantification (CTP MBF) using dynamic, 4-dimensional, dynamic stress myocardial computed tomography perfusion (CTP) imaging.METHODS In total, 7 centers participating in the prospective AMPLIFIED (Assessment of Myocardial Perfusion Linked to Infarction and Fibrosis Explored with Dual-source CT) study acquired CTP and CTA data in patients with suspected or known CAD. Hemodynamically relevant CAD was defined as >= 90% stenosis on invasive coronary angiography or fractional flow reserve