Infantile hemangiopericytoma of the tongue-Efficacy of ex utero intrapartum treatment procedure and combined-modality therapy.
Infantile hemangiopericytoma of the tongue-Efficacy of ex utero intrapartum treatment procedure and combined-modality therapy.
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婴儿舌血管外皮细胞瘤——宫外产时治疗程序和联合治疗的疗效。
DOI：
10.1016/j.anl.2017.02.009
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Katori Y.
中科院分区：
文献类型：
--
作者：
Ogawa T;Ishii R;Ozawa D;Rikiishi T;Usubuchi H;Watanabe M;Imai Y;Sato K;Saito M;Sasahara Y;Matsuda T;Kure S;Katori Y.
在此，我们提出一个极为罕见的情况下，巨大婴儿血管外皮细胞瘤（HPC）的舌头产前诊断胎儿超声和磁共振成像。由于气道狭窄，患者在妊娠36周时通过子宫外产时治疗（EXIT）手术分娩。根据体格检查、影像学诊断及血管瘤的高发病率，初步诊断为婴幼儿血管瘤。肿瘤对保守治疗有抵抗力。由于严重的肿瘤出血，在出生后第73天通过血管内治疗栓塞营养血管。栓塞后2天，进行了半舌切除术。手术后组织学分析诊断为小儿HPC，残端镜检阳性。在接受辅助化疗后，患者在53个月后没有复发，言语和吞咽功能正常，导致正常生长。我们的研究结果支持婴儿HPC是婴儿血管瘤的鉴别诊断之一。EXIT手术对产前诊断为头颈部肿瘤的上呼吸道狭窄的婴儿是有效的。虽然婴儿型HPC需要完全切除，但我们的报告建议，对于巨大头颈部的婴儿型HPC，应采用保守的手术方式，然后辅以化疗。
Here we present an extremely rare case of giant infantile hemangiopericytoma (HPC) of the tongue diagnosed prenatally by fetal ultrasonography and MR imaging. Due to airway stenosis, the patient was delivered by the ex utero intrapartum treatment (EXIT) procedure at 36 weeks of pregnancy. Initial diagnosis was infantile hemangioma based on physical examination, diagnostic imaging and the high incidence of hemangioma. The tumor was resistant to conservative treatments. Due to severe tumor hemorrhage, the nutrient vessel was embolized by endovascular treatment on the 73th day after birth. Two days after embolization, a hemiglossectomy was performed. Histological analysis after surgery diagnosed infantile HPC with microscopically positive stumps. After receiving adjuvant chemotherapy, the patient has had no recurrence after 53 months with normal speech and swallowing function resulting in normal growth. Our findings support that infantile HPC is one of the differential diagnosis of infantile hemangioma. The EXIT procedure could be effective for infants with upper respiratory stenosis by head and neck tumor diagnosed prenatally. Though complete resection is required for infantile HPC, our report suggests that a conservative surgical approach followed by adjuvant chemotherapy should be used for giant head and neck infantile HPC.