Hand motor cortex activation in a patient with congenital mirror movements: A study of the silent period following focal transcranial magnetic stimulation
Hand motor cortex activation in a patient with congenital mirror movements: A study of the silent period following focal transcranial magnetic stimulation
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DOI：
10.1016/0924-980x(96)95621-0
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发表时间：
1996-06-01
期刊：
影响因子：
--
通讯作者：
Ragazzoni, A
中科院分区：
文献类型：
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作者：
Cincotta, M;Lori, S;Ragazzoni, A
运动诱发电位 (MEP) 到局灶性经颅磁刺激 (TMS) 表明，先天性镜像运动患者的同侧皮质脊髓投射异常活跃。此外，运动相关电位和 PET 表明运动皮层激活的异常模式可能与皮质脊髓束的异常有关。在本研究中，对一名患有家族性先天性镜像运动的女性进行了局灶性 TMS 后的静默期 (SP) 调查。记录是从两个拇短展肌 (APB) 肌肉进行的。当在预期的对侧 APE 肌肉收缩期间传递局灶性 TMS 时，双侧记录 MEP 和 SP，并且 SP 明显短于正常对照中观察到的对侧 SP。手部运动皮层的异常双侧激活可以解释我们的发现。当受刺激的运动皮层仍受到抑制时（一旦经胼胝体抑制和短暂的节段抑制都完成就开始），未受刺激的运动皮层会导致背景肌电图活动的早期部分恢复。
Motor evoked potentials (MEPs) to focal transcranial magnetic stimulation (TMS) have demonstrated that abnormal ipsilateral corticospinal projections are active in patients with congenital mirror movements. In addition, movement-related potentials and PET suggest that an abnormal pattern of motor cortex activation could be associated with an anomaly of the corticospinal tracts. In the present study the silent period (SP) following focal TMS was investigated in a woman with familial congenital mirror movements. Recordings were made from both the abductor pollicis brevis (APB) muscles. When focal TMS was delivered during an intended contralateral APE muscle contraction, MEP and SP were bilaterally recorded and SP was significantly shorter than the contralateral SP observed in normal controls. An abnormal bilateral activation of the hand motor cortex can explain our findings. The non-stimulated motor cortex causes an early partial recovery of the background EMG activity when the stimulated motor cortex is still inhibited (beginning as soon as the transcallosal and the short-lasting segmental inhibition are both complete).