Asthma control and cognitive function in a cohort of elderly adults.
Asthma control and cognitive function in a cohort of elderly adults.
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DOI：
10.1111/jgs.13350
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发表时间：
2015-04
影响因子：
6.3
通讯作者：
Federman AD
中科院分区：
文献类型：
--
作者：
Ray M;Sano M;Wisnivesky JP;Wolf MS;Federman AD
哮喘患者认知障碍的风险增加。然而，在老年人中，哮喘控制与认知表现之间的联系还没有得到严格的评估。我们在一群年长的内城哮喘患者中检验了哮喘控制不良与认知障碍相关的假设。60岁以上的被医生诊断为哮喘的成年人是从纽约和芝加哥的门诊招募的。排除了有慢性阻塞性肺疾病和≥10包年吸烟史的患者。认知评估包括加工速度(模式比较，轨迹A)、执行功能(轨迹B)、注意力和工作记忆(字母数字排序)、即时和延迟回忆(韦氏记忆量表故事A)、单词流畅性(动物命名)和全局认知功能(简易智力状态测试)。用哮喘控制问卷(ACQ)测量哮喘控制情况，用肺活量测定法测量预测的1秒用力呼气量(FEV1)和70%的气道阻塞程度。认知测量在线性和逻辑回归模型中建模，控制了年龄、种族、教育程度、英语水平和收入。452名参与者的平均年龄为68岁；41%的人哮喘控制不佳，35%的人FEV1和70%的人患有哮喘。在单变量分析中，哮喘控制不良70%与所有认知功能指标显著相关。然而，在调整了年龄、教育程度、英语口语能力和其他协变量后，这些关联失去了统计意义。在基于标准数据的认知测量中，当结果低于正常表现时，也观察到了同样的模式。在患有哮喘的老年人中，哮喘控制不佳和呼吸道阻塞与认知功能的各种指标表现不佳无关。
Asthmatics are at increased risk for cognitive impairment. The association of asthma control with cognitive performance, however, has not been rigorously assessed among older adults. We examined the hypothesis that poor asthma control is associated with cognitive impairment in a cohort of older, inner-city asthmatics. Adults ages 60+ years with a physician diagnosis of asthma were recruited from outpatient practices in New York City and Chicago. Patients with chronic obstructive pulmonary disease and ≥10 pack-year smoking histories were excluded. Cognitive assessments included processing speed (pattern comparison, Trails A), executive function (Trails B), attention and working memory (letter number sequencing), immediate and delayed recall (Wechsler Memory Scale Story A), word fluency (animal naming), and global cognitive function (Mini-Mental State Exam). Asthma control was measured with the Asthma Control Questionnaire (ACQ) and airway obstruction by spirometry as the predicted forced expiratory volume at 1-second (FEV1) <70%. Cognitive measures were modeled in linear and logistic regression models controlling for age, race, education, English proficiency, and income. The 452 participants had a mean age of 68; 41% had poor asthma control by the ACQ and 35% had FEV1<70%. Poor asthma controland FEV1<70% were significantly associated with all measures of cognitive function in univariate analyses. However, these associations lost their statistical significance after adjusting for age, education, English speaking ability and other covariates. The same pattern was observed when the outcomes were below normal performance on the cognitive measures based on normative data. Among older adults with asthma, poor asthma control and airway obstruction are not associated with poor performance on various measures of cognitive function.
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DOI：
10.1016/j.jaci.2011.06.048
发表时间：
2011-09
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Hanania NA;King MJ;Braman SS;Saltoun C;Wise RA;Enright P;Falsey AR;Mathur SK;Ramsdell JW;Rogers L;Stempel DA;Lima JJ;Fish JE;Wilson SR;Boyd C;Patel KV;Irvin CG;Yawn BP;Halm EA;Wasserman SI;Sands MF;Ershler WB;Ledford DK;Asthma in Elderly workshop participants
通讯作者：
Asthma in Elderly workshop participants
影响因子：
4.3
作者：
Juniper, EF;Bousquet, J;Bateman, ED
通讯作者：
Bateman, ED
影响因子：
2.9
作者：
Duong, TH;Acton, PJ;Johnson, RA
通讯作者：
Johnson, RA
影响因子：
6.7
作者：
Federman, Alex D.;Cole, Helen;Sano, Mary
通讯作者：
Sano, Mary
影响因子：
14
作者：
Benson, Gloria;de Felipe, Jesus;Sano, Mary
通讯作者：
Sano, Mary