Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
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DOI：
10.1007/s12603-022-1758-z
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发表时间：
2022
影响因子：
5.8
通讯作者：
Cruz-Almeida, Y.
中科院分区：
文献类型：
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作者：
Strath, L. J.;Meng, L.;Rani, A.;Sinha, P.;Johnson, A. J.;Huo, Z.;Foster, T. C.;Edburg, J. D.;Fillingim, R. B.;Cruz-Almeida, Y.
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship. Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2). 189 individuals aged 45–65 years and older. Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses. Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = −0.0799; CI [−0.1492, −0.0237]) and disability (ab = −0.0669; CI [−0.1365, −0.0149]) outcomes. These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
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影响因子：
5.9
作者：
Remely M;Ferk F;Sterneder S;Setayesh T;Kepcija T;Roth S;Noorizadeh R;Greunz M;Rebhan I;Wagner KH;Knasmüller S;Haslberger A
通讯作者：
Haslberger A
影响因子：
4.1
作者：
Fleet JC
通讯作者：
Fleet JC
影响因子：
3.3
作者：
Moore, Jerott R.;Hubler, Shane L.;Hayes, Colleen E.
通讯作者：
Hayes, Colleen E.
影响因子：
5.7
作者：
Gao X;Zhang Y;Schöttker B;Brenner H
通讯作者：
Brenner H
DOI：
10.1016/j.ynpai.2021.100066
发表时间：
2021-08
期刊：
Neurobiology of pain (Cambridge, Mass.)
影响因子：
--
作者：
Marques Miranda C;de Lima Campos M;Leite-Almeida H
通讯作者：
Leite-Almeida H