A photoactivated prodrug.
A photoactivated prodrug.
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DOI：
10.1016/s0960-894x(98)00437-5
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发表时间：
1998-09
影响因子：
2.7
通讯作者：
Y. Wei;Y. Yan;D. Pei;B. Gong
中科院分区：
文献类型：
--
作者：
Y. Wei;Y. Yan;D. Pei;B. Gong
设计并合成了抗癌药物 5-氟脱氧尿苷 (2) 的光不稳定衍生物 (1) 作为模型前药。 1 用长波长紫外光光解，在溶液中迅速释放出 2。虽然单独的化合物 1 对细胞无毒，但 1 和紫外线照射 (λ = 350 nm) 的存在会导致细胞生长的有效抑制。
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (λ = 350 nm) resulted in potent inhibition of cell growth.