Histone modifications and their role in epigenetics of atopy and allergic diseases.
Histone modifications and their role in epigenetics of atopy and allergic diseases.
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DOI：
10.1186/s13223-018-0259-4
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Potaczek DP
中科院分区：
文献类型：
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作者：
Alaskhar Alhamwe B;Khalaila R;Wolf J;von Bülow V;Harb H;Alhamdan F;Hii CS;Prescott SL;Ferrante A;Renz H;Garn H;Potaczek DP
这篇综述涵盖了组蛋白修饰的基本方面和翻译后组蛋白修饰在过敏性疾病发展中的作用，包括这种发展背后的免疫机制。与DNA甲基化一起，组蛋白修饰（包括组蛋白乙酰化、甲基化、磷酸化、泛素化等）代表了经典的表观遗传机制。然而，在过敏的背景下，对组蛋白修饰的关注远远少于对DNA甲基化的关注。对文献进行了系统的回顾，以提供对组蛋白修饰在过敏中的参与及其发展的机制的公正和全面的更新。除了涵盖对组蛋白修饰在调节过敏性疾病发展中的贡献日益增长的兴趣外，本综述还总结了一些支持这一贡献的证据。至少在两个层面上，组蛋白修饰的作用得到了体现。一种是参与过敏性炎症的细胞（T细胞和巨噬细胞）和参与气道重塑的细胞（肌-）成纤维细胞)的调节。另一种是组蛋白修饰与过敏表型之间的直接关联。组蛋白修饰酶抑制剂可能被用作抗过敏药物。此外，表观遗传模式可能为过敏性疾病的诊断提供新的工具。
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of histone modifications in allergy and the mechanisms underlying this development. In addition to covering the growing interest in the contribution of histone modifications in regulating the development of allergic diseases, this review summarizes some of the evidence supporting this contribution. There are at least two levels at which the role of histone modifications is manifested. One is the regulation of cells that contribute to the allergic inflammation (T cells and macrophages) and those that participate in airway remodeling [(myo-) fibroblasts]. The other is the direct association between histone modifications and allergic phenotypes. Inhibitors of histone-modifying enzymes may potentially be used as anti-allergic drugs. Furthermore, epigenetic patterns may provide novel tools in the diagnosis of allergic disorders.