Combination of Orthogonal ABB and ABC Multicomponent Reactions toward Efficient Divergent Synthesis of Dendrimers with Structural Diversity
Combination of Orthogonal ABB and ABC Multicomponent Reactions toward Efficient Divergent Synthesis of Dendrimers with Structural Diversity
复制标题
DOI：
10.1021/mz500207z
复制
发表时间：
2014-07-01
影响因子：
7.015
通讯作者：
Li, Zi-Chen
中科院分区：
文献类型：
--
作者：
Deng, Xin-Xing;Du, Fu-Sheng;Li, Zi-Chen
树状大分子的合成一直朝着工艺效率和结构多样性的方向发展。本文报道了一种由无分支单体结合ABC - Passerini多组分高效正交反应（MCR）和ABB -硫醇炔多组分反应（MCR）制备具有ABC和ABB分支结构的树状大分子的发散方法。通过三步合成了两种树状大分子：(1)两代树状大分子和(2)两代树状大分子分别含有一种内部官能团和两种表面官能团，共五步合成。这种新的合成方法为结构多样的树状大分子提供了有效的途径。
Synthesis of dendrimers has been directed toward process efficiency and structural diversity. We report a divergent approach to the preparation of dendrimers with both ABC and ABB branching structures from nonbranching monomers by combination of efficient orthogonal ABC Passerini multicomponent reaction (MCR) and ABB thiol-yne MCR. Two kinds of dendrimers were synthesized efficiently: (1) dendrimers with two generations in three steps and (2) dendrimers with two generations containing one kind of internal functional group and two kinds of surface functional groups in five steps. This new synthetic method offers an efficient access to dendrimers with structural diversity.