Patterns of Cortical Input to the Primary Motor Area in the Marmoset Monkey
Patterns of Cortical Input to the Primary Motor Area in the Marmoset Monkey
复制标题
DOI：
10.1002/cne.23447
复制
发表时间：
2014-03-01
影响因子：
2.5
通讯作者：
Rosa, Marcello G. P.
中科院分区：
文献类型：
--
作者：
Burman, Kathleen J.;Bakola, Sophia;Rosa, Marcello G. P.
在灵长类动物中，初级运动皮质(M1)形成了身体的地形图，该区域内侧部分的神经元控制涉及躯干和后肢肌肉的运动，中间部分的神经元控制涉及前肢肌肉的运动，而外侧部分的神经元控制面部和其他头部肌肉的运动。这种地形伴随着细胞结构特征的变化，这提出了一个问题，即M1不同部分之间的解剖联系是否也不同。为了解决这个问题，我们比较了逆行注射示踪剂在绒猴M1内不同位置所揭示的皮质传入模式。我们发现，这个区域的整个范围是由运动前皮质的背尾部和内侧亚区(6DC和6M区)，来自躯体感觉区3a、3b、1/2和S2区，以及来自顶后PE区的投射统一的。虽然扣带区投射到所有分区，但它们优先定位于M1的内侧部分。相反，腹侧运动前区优先与M1外侧区相连。额叶6DR区、顶叶腹侧后皮质、岛叶后皮质和TPT区有较小但一致的投射。与顶叶内、前额叶和颞区的联系非常稀疏和多变。我们的结果表明，M1是由一个一致的主要联系模式统一的，但也显示出次要输入的地区差异。这些差异可能反映了对涉及不同身体部位的自愿运动的控制要求。J.Comp.神经。2014年522：811-843。(C)2013年威利期刊公司。
In primates the primary motor cortex (M1) forms a topographic map of the body, whereby neurons in the medial part of this area control movements involving trunk and hindlimb muscles, those in the intermediate part control movements involving forelimb muscles, and those in the lateral part control movements of facial and other head muscles. This topography is accompanied by changes in cytoarchitectural characteristics, raising the question of whether the anatomical connections also vary between different parts of M1. To address this issue, we compared the patterns of cortical afferents revealed by retrograde tracer injections in different locations within M1 of marmoset monkeys. We found that the entire extent of this area is unified by projections from the dorsocaudal and medial subdivisions of premotor cortex (areas 6DC and 6M), from somatosensory areas 3a, 3b, 1/2, and S2, and from posterior parietal area PE. While cingulate areas projected to all subdivisions, they preferentially targeted the medial part of M1. Conversely, the ventral premotor areas were preferentially connected with the lateral part of M1. Smaller but consistent inputs originated in frontal area 6DR, ventral posterior parietal cortex, the retroinsular cortex, and area TPt. Connections with intraparietal, prefrontal, and temporal areas were very sparse, and variable. Our results demonstrate that M1 is unified by a consistent pattern of major connections, but also shows regional variations in terms of minor inputs. These differences likely reflect requirements for control of voluntary movement involving different body parts. J. Comp. Neurol. 522:811-843, 2014. (c) 2013 Wiley Periodicals, Inc.