L-type calcium channels govern calcium signaling in migrating newborn neurons in the postnatal olfactory bulb.
L-type calcium channels govern calcium signaling in migrating newborn neurons in the postnatal olfactory bulb.
复制标题
DOI：
10.1523/jneurosci.5333-08.2009
复制
发表时间：
2009-02-25
期刊：
影响因子：
--
通讯作者：
Isaacson JS
中科院分区：
文献类型：
--
作者：
Darcy DP;Isaacson JS
新生的抑制性神经元在成年哺乳动物的一生中迁移到嗅球中现有的神经回路中。虽然许多因素有助于神经回路的成熟，但细胞内钙被认为在调节细胞迁移和神经系统发育中起重要作用。然而，出生后嗅球中新生神经元内钙信号的潜在因素还不清楚。在这里，我们表明，迁移，在嗅球室管膜下层（SEL）的未成熟神经元进行自发和去极化诱发的细胞内钙瞬变介导的高电压激活的L-型钙通道。与其他脑区中迁移的未成熟神经元相反，SEL细胞中钙瞬变的调节不会改变其迁移速率。
Newborn inhibitory neurons migrate into existing neural circuitry in the olfactory bulb throughout the lifetime of adult mammals. While many factors contribute to the maturation of neural circuits, intracellular calcium is believed to play an important role in regulating cell migration and the development of neural systems. However, the factors underlying calcium signaling within newborn neurons in the postnatal olfactory bulb are not well understood. Here we show that migrating, immature neurons in the olfactory bulb subependymal layer (SEL) undergo spontaneous and depolarization-evoked intracellular calcium transients mediated by high voltage-activated L-type calcium channels. In contrast to migrating immature neurons in other brain regions, modulation of calcium transients in SEL cells does not alter their rate of migration.