Uric acid is associated with future atrial fibrillation: an 11-year follow-up of 6308 men and womenuthe Troms Study
Uric acid is associated with future atrial fibrillation: an 11-year follow-up of 6308 men and womenuthe Troms Study
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DOI：
10.1093/europace/eut260
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发表时间：
2014-03-01
期刊：
影响因子：
6.1
通讯作者：
Lochen, Maja-Lisa
中科院分区：
文献类型：
--
作者：
Nyrnes, Audhild;Toft, Ingrid;Lochen, Maja-Lisa
在人群研究中，血清尿酸（SUA）与心血管疾病相关，但其与心房颤动（AF）的关系在很大程度上尚不清楚。本研究的目的是在大型人群队列中调查基线 SUA 与未来 AF 之间的关联。 199495 年挪威特罗姆斯人口调查中共有 6308 名男性和女性，随访时间为 10.8 年。基线平均年龄为 60 岁。在基线时获得有关心绞痛、心肌梗塞、糖尿病、抗高血压和利尿治疗、体力活动、吸烟和饮酒的信息，以及身高、体重、血压、SUA、总胆固醇和高密度脂蛋白胆固醇的测量值。结果测量是首次出现房颤，记录在心电图上。我们发现了 572 例房颤事件。在针对心血管危险因素和伴随疾病进行调整的多变量 Cox 比例风险回归分析中，男女性 SUA 均与 AF 相关。 SUA (91 mol/L) 每增加 1 个 SD，女性的风险比为 1.40 [95 CI, 1.141.72]，男性为 1.17 (95 CI, 1.021.36)。与最低四分位相比，SUA 的上四分位数使女性房颤风险增加 76 倍，男性房颤风险增加 49 倍。这项基于人群的前瞻性队列研究表明，基线 SUA 与男女未来房颤风险增加相关。
Serum uric acid (SUA) has been associated with cardiovascular disease in population studies, but its relation to atrial fibrillation (AF) is largely unknown. The aim of this study was to investigate the association between baseline SUA and future AF in a large population-based cohort.A total of 6308 men and women from a population survey in Troms, Norway in 199495 were followed-up for 10.8 years. The mean age at baseline was 60 years. Information on angina, myocardial infarction, diabetes, anti-hypertensive and diuretic treatment, physical activity, smoking and alcohol, and measurements of height, weight, blood pressure, SUA, total cholesterol, and high density lipoprotein-cholesterol were obtained at baseline. The outcome measure was first-ever AF, documented on an electrocardiogram. We identified 572 cases of incident AF. In multivariable Cox proportional hazards regression analysis adjusted for cardiovascular risk factors and concomitant diseases, SUA was associated with AF in both sexes. Hazard ratio per 1 SD increase in SUA (91 mol/L) was 1.40 [95 confidence intervals (CI), 1.141.72] in women and 1.17 (95 CI, 1.021.36) in men. The upper quartile of SUA conferred a 76 increased risk for AF in women and 49 in men as compared with the lowest quartile.This prospective population-based cohort study showed that baseline SUA was associated with an increased risk for future AF in both sexes.