The immunology of tuberculosis: from bench to bedside.
The immunology of tuberculosis: from bench to bedside.
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DOI：
10.1111/j.1440-1843.2010.01739.x
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
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作者：
Dheda K;Schwander SK;Zhu B;van Zyl-Smit RN;Zhang Y
结核病(TB)是国际公共卫生优先事项，每年导致近200万人死亡。由于日益增加的贫困和艾滋病毒混合感染，结核病在非洲失控，耐药结核病威胁着世界几个地区结核病控制工作的稳定。现有的结核病诊断工具和治疗干预措施并不理想。因此，迫切需要新的疫苗、免疫治疗干预措施和诊断工具来促进结核病控制工作。提高对结核病免疫发病机制的认识，有助于识别免疫保护的相关因素，设计有效的疫苗，合理选择免疫治疗药物，评估新药候选，并推动新的免疫诊断工具的发展。在这里，我们回顾了结核病的免疫学，重点放在与临床和治疗相关的方面。只有同时努力减轻贫困和减轻全球艾滋病毒负担，以免疫为导向的防治结核病的方法才能取得成功。
Tuberculosis (TB) is an international public health priority and kills almost two million people annually. TB is out of control in Africa due to increasing poverty and HIV coinfection, and drug-resistant TB threatens to destabilize TB control efforts in several regions of the world. Existing diagnostic tools and therapeutic interventions for TB are suboptimal. Thus, new vaccines, immunotherapeutic interventions and diagnostic tools are urgently required to facilitate TB control efforts. An improved understanding of the immunopathogenesis of TB can facilitate the identification of correlates of immune protection, the design of effective vaccines, the rational selection of immunotherapeutic agents, the evaluation of new drug candidates, and drive the development of new immunodiagnostic tools. Here we review the immunology of TB with a focus on aspects that are clinically and therapeutically relevant. An immunologically orientated approach to tackling TB can only succeed with concurrent efforts to alleviate poverty and reduce the global burden of HIV.