Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis
Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis
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DOI：
10.1111/j.1600-051x.2004.00492.x
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发表时间：
2004-05-01
影响因子：
6.7
通讯作者：
Meyle, J
中科院分区：
文献类型：
--
作者：
Gonzales, JR;Kobayashi, T;Meyle, J
目的：近年来，白细胞介素（IL）4基因多态性与牙周炎的关系进行了研究。以前已经检测到高加索人和日本人牙周炎患者之间的遗传差异。本研究的目的是分析白细胞介素-4基因型在白人和日本患者侵袭性牙周炎（AgP）。材料和方法：124名受试者，31名日本和30名白人患者全身AgP，加上30名日本和33名白人健康对照。聚合酶链反应检测IL-4基因多态性。Logistic回归分析被用来调查可能的关联基因型与疾病在这两个群体。优势比（OR）估计进行了分析等位基因frequency.Results：没有显着关联的IL-4多态性与AgP的风险被确定在任何人群。然而，等位基因频率显示不同的群体之间的结果。与对照组相比，白种人患者内含子2的多态性携带率更高（OR：2.0，95%置信区间：[1.0;4.2]。此外，发现患者和对照组中IL-4启动子/内含子2复合基因型（PP+/IP+）的频率在日本人群中分别比高加索人群高约25%和60%。在两个人群中均没有证据表明IL-4基因型与AgP相关，虽然日本人和高加索人IL-4基因型的频率不同。
Objectives: Recently, interleukin (IL) 4 gene polymorphisms have been analyzed in association with periodontitis. Genetic differences between Caucasian and Japanese patients with periodontitis have previously been detected. The aim of the present study was to analyze IL-4 genotypes in Caucasian and Japanese patients with aggressive periodontitis (AgP).Material and Methods: One hundred and twenty-four subjects were included in the study, 31 Japanese and 30 Caucasian patients with generalized AgP, plus 30 Japanese and 33 Caucasian healthy controls. IL-4 polymorphisms were determined by polymerase chain reaction. A logistic regression was used to investigate the possible association of the genotypes with the disease in both populations. Odds ratio (OR) estimates were analyzed for allele frequencies.Results: No significant association of IL-4 polymorphisms with the risk of AgP was determined in either population. However, the allele frequencies showed different results between populations. The carriage of the polymorphism in intron 2 was higher in Caucasian patients compared with controls (OR: 2.0, 95% confidence interval: [1.0;4.2]. Furthermore, the frequency of the IL-4 promoter/intron 2 composite genotype (PP+/IP+) in patients and controls, respectively, was found to be approximately 25% and 60% higher in the Japanese population than in the Caucasian population.Conclusion: There was no evidence of an association of IL-4 genotypes and AgP in either population, although the frequencies of the IL-4 genotypes in the Japanese and the Caucasians were different.