Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles
Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles
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DOI：
10.1098/rstb.1997.0139
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发表时间：
1997-10-29
影响因子：
6.3
通讯作者：
Barnes, CA
中科院分区：
文献类型：
--
作者：
Qin, YL;McNaughton, BL;Barnes, CA
海马神经细胞在行为过程中一起放电，在随后的睡眠中表现出增强的活动相关性，并保留了一些时间顺序信息。因此，在随后的“离线”期间，反映行为过程中的经验的信息在海马回路中重新表达，正如一些记忆巩固理论所假设的那样。如果海马协调新皮层中经验特异性活动模式的恢复，正如这些理论所假设的那样，那么新皮层内以及海马和新皮层之间的相关模式也应该在睡眠期间重新出现。在7只大鼠的后顶叶新皮层中，在CA1d中，同时在两个区域中进行了记录。每个阶段包括初始睡眠（S1），简单迷宫（M）和随后的睡眠（S2）。在S2期间，区域内和区域间的总体活动相关结构与M的相关模式比S1的更接近。时间顺序（即交叉相关图的不对称性）也被保留在结构内，而不是结构之间。因此，在睡眠期间，最近经历的痕迹在海马和新皮层回路中重新表达，并且这两个区域中的表征往往对应于相同的经历。不同区域中神经元之间的时间放电偏差保存较差，可能反映了区域之间的突触耦合不如区域内的直接。或者，它可能是由一个转变，行为状态之间，在相对优势关系的corticohippocampal对话。例如，如果在行为过程中，新皮层模式倾向于驱动相应的海马模式，而在睡眠过程中则相反。这种可能性仍有待调查。
Hippocampal cells that fire together during behaviour exhibit enhanced activity correlations during subsequent sleep, with some preservation of temporal order information. Thus, information reflecting experiences during behaviour is re-expressed in hippocampal circuits during subsequent 'offline' periods, as postulated by some theories of memory consolidation If the hippocampus orchestrates the reinstatement of experience-specific activity patterns in the neocortex, as also postulated by such theories, then correlation patterns both within the neocortex and between hippocampus and neocortex should also re-emerge during sleep. Ensemble recordings were made in the posterior parietal neocortex, in CA1d and simultaneously in both areas, in seven rats. Each session involved an initial sleep episode (S1), behaviour on a simple maze (M), and subsequent sleep (S2). The ensemble activity-correlation structure within and between areas during S2 resembled that of M more closely than did the correlation pattern of S1. Temporal order (i.e. the asymmetry of the cross-correlogram) was also preserved within, but not between, structures. Thus, traces of recent experience are re-expressed in both hippocampal and neocortical circuits during sleep, and the representations in the two areas tend to correspond to the same experience. The poorer preservation of temporal firing biases between neurons in the different regions may reflect the less direct synaptic coupling between regions than within them. Alternatively, it could result from a shift, between behavioural states, in the relative dominance relations in the corticohippocampal dialogue. Between structure order will be disrupted, for example, if during behaviour, neocortical patterns tend to drive corresponding hippocampal patterns, whereas during sleep the reverse occurs. This possibility remains to be investigated.