Antioxidant intake and status, and oxidative stress in relation to breast cancer risk: a case-control study.
Antioxidant intake and status, and oxidative stress in relation to breast cancer risk: a case-control study.
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抗氧化剂的摄入量和状态以及与乳腺癌风险相关的氧化应激：病例对照研究。
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发表时间：
2008
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通讯作者：
M. Fairulnizal
中科院分区：
文献类型：
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作者：
S. Sharhar;H. Normah;A. Fatimah;R. Fadilah;G. A. Rohi;I. Amin;B. Cham;R. Rizal;M. Fairulnizal
进行了一项病例对照研究，以调查巴生谷和雪兰莪州妇女乳腺癌风险，抗氧化状态和氧化应激之间的关系。共有57名年龄在30至66岁之间的新诊断病例参与了研究，并与139名未诊断出癌症或其他慢性疾病的对照组进行了年龄和种族匹配。采用基于访谈的问卷调查，旨在收集人口统计学和社会经济状况以及生殖、医疗和饮食史的信息。进行人体测量，包括体重、身高、腰围和臀围，并采集10 ml空腹静脉血样本进行血糖检测和血浆维生素抗氧化剂和丙二醛分析。采集头发和脚趾甲样品进行硒分析。结果表明，维生素A、维生素E、硒的平均摄入量（606.8 +/- 334.8微克/天，6.1 +/- 2.4克/天，56.9 +/- 16.2微克/天）低于对照组（分别为724.7 +/- 414微克/天、6.9 +/- 3.0克/天、60.8 +/- 17.5微克/天）（所有参数p<0.05）。血浆维生素A和E以及头发和脚趾甲中的硒也有类似的趋势。抗氧化状态差，表现为血浆维生素A水平低（<284.3微克/升或<366.3微克/升）增加乳腺癌的风险约两倍，而低血浆维生素E，（<2.5 mg/dl、<2.8 mg/dl和<3.1 mg/dl）的风险增加2 - 3倍[校正OR 2.97（95% CI 1.38-3.48）、2.32（95% CI 1.07-2.41）和2.12（95% CI 1.00-4.21）]。与对照组（3.2 +/-1.7 mmol/g蛋白质）相比，病例具有更高水平的丙二醛（4.4 +/-1.1 mmol/g蛋白质），这是氧化应激的指标（p<0.05）。高水平的MDA（>或= 4.8 mmol/g蛋白）与乳腺癌相关[校正OR 6.82（95% CI 1.95-23.9）]。它的结论是，一个穷人的抗氧化状态和高氧化应激与乳腺癌的风险。因此，马来西亚妇女必须通过食用富含维生素A和E以及硒的饮食获得良好的抗氧化状态，并采取健康的行为减少氧化应激，以预防乳腺癌。
A case control study was carried out to investigate associations between breast cancer risk, antioxidant status and oxidative stress among women in Klang Valley and Selangor. A total of 57 newly diagnosed cases aged 30 to 66 years old participated and were matched for age and ethnicity with 139 controls with no diagnosis of cancer or other chronic diseases. An interview based questionnaire designed to collect information on demographic and socioeconomic status, as well as reproductive, medical and dietary history was used. Anthropometric measurements including weight, height, waist and hip circumference were made and a 10 ml fasting venous blood sample was taken for glucose testing and analysis of plasma vitamin antioxidants and malondialdehyde. Hair and toenail samples were taken for selenium analysis. Results showed that the mean intake of vitamin A, vitamin E and selenium among cases (606.8 +/- 334.8 microg/d, 6.1 +/- 2.4 g/d, 56.9 +/- 16.2 microg/d) was lower than controls (724.7 +/- 414 microg/day, 6.9 +/- 3.0 g/d, 60.8 +/- 17.5 microg/d, respectively) (p<0.05 for all parameters). A similar trend was noted for plasma vitamin A and E and also selenium in hair and toenails. Poor antioxidant status as indicated by low plasma vitamin A (<284.3 microg/l or <366.3 microg/l) increased risk of breast cancer by approximately two fold, whilst low plasma vitamin E (<2.5 mg/dl, <2.8 mg/dl and <3.1 mg/dl) increased the risk by two to three fold [Adjusted OR 2.97 (95% CI 1.38-3.48), 2.32 (95% CI 1.07-2.41) and 2.12 (95% CI 1.00-4.21)]. Cases had a greater level of malondialdehyde 4.4 +/- 1.1 mmol/g protein), an indicator of oxidative stress, as compared to controls (3.2 +/- 1.7 mmol/g protein) (p<0.05). A high level of MDA (> or = 4.8 mmol/g protein) was associated with breast cancer [Adjusted OR 6.82 (95% CI 1.95-23.9)]. It is concluded that a poor antioxidant status and high oxidative stress are associated with breast cancer risk. Thus, it is essential for Malaysian women to obtain a good antioxidant status by consuming a diet rich in vitamins A and E as well as selenium and adopt healthy behaviour to reduce oxidative stress in order to prevent breast cancer.