Effects of moderate alcohol consumption on cognitive function in women
Effects of moderate alcohol consumption on cognitive function in women
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DOI：
10.1056/nejmoa041152
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发表时间：
2005-01-20
影响因子：
158.5
通讯作者：
Grodstein, F
中科院分区：
文献类型：
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作者：
Stampfer, MJ;Kang, JH;Grodstein, F
背景：过量饮酒对认知功能的不良影响是公认的，但适度饮酒的影响是不确定的。方法：在1995年和2001年之间，我们评估了12,480名参加护士健康研究的70至81岁的参与者的认知功能，两年后随访评估了11,102人。从1980年开始，定期确定酒精消费水平。我们计算了多变量调整后的平均认知评分和多变量调整后的认知障碍风险（定义为评分最低的10%）以及随着时间的推移认知功能的大幅下降（定义为下降分布中最差的10%）。我们还分层分析，根据载脂蛋白E基因型在一个亚组的women.RESULTS：多变量调整后，适度饮酒者（那些谁消耗少于15.0克的酒精，每天[约一杯]）有更好的平均认知得分比nondirinks。在中度饮酒者中，与不饮酒者相比，在我们的一般认知测试中，受损的相对风险为0.77（95%置信区间，0.67至0.88），在综合所有测试结果的总体认知评分基础上，受损的相对风险为0.81（95%置信区间，0.70至0.93）。认知能力下降的结果是相似的;例如，在我们的一般认知测试中，与不饮酒者相比，适度饮酒者在两年期间表现大幅下降的相对风险为0.85（95%置信区间为0.74 ~ 0.98）。高水平饮酒（每天15.0至30.0克）与认知功能障碍或下降的风险之间没有显着关联。根据饮料的不同，风险没有显著差异（例如，结论：我们的数据表明，在女性中，每天最多喝一杯酒不会损害认知功能，实际上可能会降低认知能力下降的风险。
BACKGROUND:The adverse effects of excess alcohol intake on cognitive function are well established, but the effect of moderate consumption is uncertain.METHODS:Between 1995 and 2001, we evaluated cognitive function in 12,480 participants in the Nurses' Health Study who were 70 to 81 years old, with follow-up assessments in 11,102 two years later. The level of alcohol consumption was ascertained regularly beginning in 1980. We calculated multivariate-adjusted mean cognitive scores and multivariate-adjusted risks of cognitive impairment (defined as the lowest 10 percent of the scores) and a substantial decline in cognitive function over time (defined as a change that was in the worst 10 percent of the distribution of the decline). We also stratified analyses according to the apolipoprotein E genotype in a subgroup of women.RESULTS:After multivariate adjustment, moderate drinkers (those who consumed less than 15.0 g of alcohol per day [about one drink]) had better mean cognitive scores than nondrinkers. Among moderate drinkers, as compared with nondrinkers, the relative risk of impairment was 0.77 on our test of general cognition (95 percent confidence interval, 0.67 to 0.88) and 0.81 on the basis of a global cognitive score combining the results of all tests (95 percent confidence interval, 0.70 to 0.93). The results for cognitive decline were similar; for example, on our test of general cognition, the relative risk of a substantial decline in performance over a two-year period was 0.85 (95 percent confidence interval, 0.74 to 0.98) among moderate drinkers, as compared with nondrinkers. There were no significant associations between higher levels of drinking (15.0 to 30.0 g per day) and the risk of cognitive impairment or decline. There were no significant differences in risks according to the beverage (e.g., wine or beer) and no interaction with the apolipoprotein E genotype.CONCLUSIONS:Our data suggest that in women, up to one drink per day does not impair cognitive function and may actually decrease the risk of cognitive decline.