THE CONCENTRATION AND CHEMICAL STATUS OF ARSENIC IN THE EARLY PLACENTAS OF ARSENATE-DOSED HAMSTERS
THE CONCENTRATION AND CHEMICAL STATUS OF ARSENIC IN THE EARLY PLACENTAS OF ARSENATE-DOSED HAMSTERS
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DOI：
10.1016/s0013-9351(87)80221-9
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发表时间：
1987-04-01
影响因子：
8.3
通讯作者：
FERM, VH
中科院分区：
文献类型：
--
作者：
HANLON, DP;FERM, VH
我们测定了仓鼠胎盘中砷的浓度和化学状态，通过渗透微型泵连续暴露于最小和坦率的致畸剂量的砷酸盐。接近70%的胎盘砷与大分子结合，其中三分之二可透析。其余30%的砷由低分子量物质组成，主要是无机砷。这种混合是相同的最低致畸和坦率致畸剂量的砷酸盐。
We determined the concentration and chemical status of arsenic in the placentas of hamsters following continuous exposure via the osmotic minipump to minimlaly and frankly teratogenic doses of arsenate. Close to 70% of the placental arsenic is bound to macromolecules, two-thirds of which is dialyzable. The remaining 30% of arsenic consists of low molecular weight species, predominantly inorganic arsenic. This mix is the same for minimally teratogenic and frankly teratogenic doses of arsenate.