Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations
Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations
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DOI：
10.1007/s001250051623
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发表时间：
2001-03-01
期刊：
影响因子：
8.2
通讯作者：
Gibson, JM
中科院分区：
文献类型：
--
作者：
Heald, AH;Cruickshank, JK;Gibson, JM
目的/假设。胰岛素抵抗/高胰岛素血症与心血管疾病和糖尿病的发展有关，但其作用和因果途径尚不清楚。我们检验了胰岛素样生长因子系统与易感人群心血管风险独立相关的假设，该假设基于先前关于低循环胰岛素样生长因子结合蛋白-1浓度与II型（非胰岛素依赖型）糖尿病大血管疾病增加之间联系的报道。在一项基于人群的研究中，272例受试者（142例欧洲受试者和130例巴基斯坦受试者）接受了75 g口服葡萄糖耐量试验和标准化人体测量。测量胰岛素样生长因子结合蛋白-1（IGFBP-1）、胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）、完整胰岛素和脂质的空腹浓度，并与2小时葡萄糖耐量试验状态相关。胰岛素敏感性采用稳态模型评估法（HOMA）计算。在两个种族中，与正常葡萄糖耐量相比，葡萄糖耐量受损受试者的胰岛素样生长因子结合蛋白-1显著降低（欧洲人F = 6.7，p = 0.002，巴基斯坦人F = 4.4，p = 0.01）。多元线性回归模型显示，胰岛素样生长因子结合蛋白-1与2小时血糖独立相关（P = 0.16，p = 0.009）和逻辑回归表明，胰岛素样生长因子结合蛋白-1浓度每增加2.7 ng/ml，葡萄糖耐量受损的风险降低40%[比值比0.6（CI = 0.49-0.71），p = 0.001）]。此外，胰岛素样生长因子结合蛋白-1显着负相关，与几个既定的心血管因素，和胰岛素敏感性呈正相关。胰岛素样生长因子结合蛋白-1与欧洲和巴基斯坦人糖尿病和心血管疾病的危险因素密切相关。在临床干预研究中，它有可能用作（肝脏）胰岛素抵抗的标志物，并进一步暗示胰岛素样生长因子系统在大血管疾病的发展中。
Aims/hypothesis. Insulin resistance/hyperinsulin-aemia is implicated in the development of cardiovascular disease and diabetes but its role and causal pathways are not clear. We tested the hypothesis that the insulin-like growth factor system is independently associated with cardiovascular risk within susceptible populations based on previous reports of the links between low circulating insulin-like growth factor binding protein-1 concentrations and increased macrovascular disease in Type II (non-insulin-dependent) diabetes mellitus.Methods. In a population-based study 272 subjects (142 subjects of European and 130 Pakistani of origin) underwent a 75 g oral glucose tolerance test and standardised anthropometry. Fasting concentrations of insulin-like growth factor binding protein-1 (IGFBP-1), insulin-like growth factor-I (IGF-I), insulinlike growth factor-II (IGF-II), intact insulin and lipids were measured and were related to 2-h glucose tolerance test status. Insulin sensitivity was calculated using the homeostasis model assessment (HOMA).Results. Insulin-like growth factor binding protein-1 was significantly lower in subjects with impaired glucose tolerance when compared with normal glucose tolerance in both ethnic groups (Europeans F = 6.7, p = 0.002 and Pakistanis F = 4.4, p = 0.01). Multiple linear regression modelling showed that insulin-like growth factor binding protein-1 was independently associated with 2-h glucose (P = 0.16, p = 0.009) and logistic regression indicated a 40 % reduction in risk of impaired glucose tolerance for every 2.7 ng/ml increase in the insulin-like growth factor binding protein-1 concentration [odds ratio 0.6 (CI = 0.49-0.71), p = 0.001)]. In addition, insulin-like growth factor binding protein-1 was significantly correlated negatively with several established cardiovascular factors, and positively with insulin sensitivity.Conclusion/interpretation. Insulin-like growth factor binding protein-1 is closely related to risk factors for diabetes and cardiovascular disease in people of European and Pakistani origin. It has potential use as a marker of (hepatic) insulin resistance in clinical intervention studies and further implicates the insulin-like growth factor system in the development of macrovascular disease.