Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults
Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults
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DOI：
10.1046/j.1365-2389.2003.51259.x
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发表时间：
2003-06-01
影响因子：
6.3
通讯作者：
Bode, C
中科院分区：
文献类型：
--
作者：
Parlesak, A;Klein, B;Bode, C
目的：确定老年人小肠细菌过度生长（SBBO）的患病率，并评估SBBO是否与腹部不适和营养摄入有关。设计：横断面调查。背景：斯图加特的八个老年住宅点，德国。参与者：独立生活在老年住宅中的老年人。测量：通过测量摄入50 g葡萄糖后呼出空气中的氢浓度（百万分之几; ppm），在328名受试者中测量SBBO的患病率，其中294名年龄在61岁及以上。获得人体测量数据和营养状况记录与计算机辅助diethistory.Results：一个积极的氢呼吸试验（>10 ppm的增加）的患病率是15.6%，在老年人，相比之下，5.9%的受试者年龄在24至59岁。胃酸生成抑制剂的摄入显著导致了老年人呼气试验阳性的高患病率，这与较低的体重、较低的体重指数、较低的血浆白蛋白浓度和较高的腹泻患病率相关。氢呼气试验阳性的受试者摄入的纤维、叶酸、维生素B-2和B-6明显少于未进行试验的受试者。在摄入的能量，蛋白质，脂肪，或碳水化合物。结论：SBBO的患病率与体重下降，这是由几种微量营养素的摄入量减少所证实。腹泻导致的吸收不良可能是导致这些受试者体重减轻的加重因素。
OBJECTIVES: To determine the prevalence of small bowel bacterial overgrowth (SBBO) in older adults and to assess whether SBBO is associated with abdominal complaints and nutrient intake.DESIGN: Cross-sectional survey.SETTING: Eight senior residence sites in Stuttgart, Germany.PARTICIPANTS: Older adults living independently in senior residence houses.MEASUREMENTS: The prevalence of SBBO was measured in 328 subjects, of whom 294 were aged 61 and older, by measuring hydrogen concentration (parts per million; ppm) in exhaled air after ingestion of 50 g glucose. Anthropometric data were obtained and nutritional status was recorded with a computer-aided diet history.RESULTS: The prevalence of a positive hydrogen breath test (>10 ppm increase) was 15.6% in older adults, compared with 5.9% in subjects aged 24 to 59. The intake of inhibitors of gastric acid production contributed significantly to the high prevalence of a positive breath test in older adults, which was associated with lower body weight, lower body mass index, lower plasma albumin concentration, and higher prevalence of diarrhea. Subjects with a positive hydrogen breath test consumed significantly less fiber, folic acid, and vitamins B-2 and B-6 than those without. No difference was observed in the intake of energy, protein, fat, or carbohydrates.CONCLUSION: Prevalence of SBBO is associated with reduced body weight, which is paralleled by reduced intake of several micronutrients. Malabsorption resulting from diarrhea might be an aggravating factor contributing to weight loss in these subjects.