IS SOMATOSTATIN AN EXCITATORY TRANSMITTER IN HIPPOCAMPUS
IS SOMATOSTATIN AN EXCITATORY TRANSMITTER IN HIPPOCAMPUS
复制标题
DOI：
10.1038/273674a0
复制
发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
KELLY, JS
中科院分区：
文献类型：
--
作者：
DODD, J;KELLY, JS
生长激素释放抑制因子，生长抑素，存在于脑的下丘脑外部位1，2表明，与其他几种生物活性肽一样，它可能是一种神经递质或中枢神经系统（CNS）神经元活动的调节剂，除了它的神经内分泌作用。在全身3、脑室4、直接小脑内5和微离子透入6，7应用后，已证实生长抑素对CNS的直接作用。此外，生长抑素集中在中枢神经系统不同区域的神经末梢中8，9，并且可以以钙依赖性方式从大鼠杏仁核和下丘脑切片中释放10。然而，生长抑素对神经元兴奋性的突触后作用的确切性质仍不清楚，已有关于兴奋性5，7和兴奋性6，11效应的报道。本文报道了生长抑素对海马CA_1和CA_2区锥体神经元胞体的作用。这些神经元位于突触后高密度的神经末梢，免疫组织化学技术显示含有生长抑素样物质12。生长抑素具有强烈的兴奋作用。
THE presence of growth hormone release inhibiting factor, somatostatin, in extrahypothalamic sites in the brain1,2suggests that, in common with several other biologically active peptides, it may be a neurotransmitter or modulator of central nervous system (CNS) neuronal activity in addition to its neuroen-docrine role. Direct actions of somatostatin on the CNS have been demonstrated following systemic3, cerebroventricular4, direct intracerebellar5and microiontophoretic6,7application. Furthermore, somatostatin is concentrated in nerve terminals in various regions of the CNS8,9and can be released in a calcium-dependent manner from slices of rat amygdala and hypothalamus10. The exact nature of the postsynaptic action of somatostatin on neuronal excitability remains unclear, however, and there have been reports of both excitatory5,7and inhibitory6,11effects. We report here our investigations on the action of somatostatin on cell bodies of hippocampal CA1 and CA2 pyramidal neurones. These neurones lie postsynaptically to high densities of nerve terminals shown by immuno-histochemical techniques to contain somatostatin-like material12. Somatostatin had a potent excitatory effect.