Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens
Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens
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DOI：
10.1021/np4007469
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发表时间：
2013-12-01
影响因子：
5.1
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Liu, Ya-Ping;Zhao, Yun-Li;Luo, Xiao-Dong
八种新的双吲哚生物碱，melosuavines A C (1-3)，具有蜘蛛乳-scandine 连接，melosuavines D F (4-6)，具有蜘蛛乳-aspidosperma 骨架，以及蜘蛛乳-venalatonine 类型的 melosuavines G 和 H (7 和 8)，tenucausine (9) 和 melodinine J (10)从 Melodinus suaveolens 的树枝和叶子中分离出来。通过广泛的光谱方法阐明了1-8的结构，并通过与文献数据比较鉴定了化合物9和10。相对构型9是从ROESY谱确定的，并且一些NMR信号被重新分配。化合物1、2、4-6、8和10对五种人类癌细胞系中的一种或多种表现出低微摩尔细胞毒性。
Eight new bisindole alkaloids, melosuavines A C (1-3), having an aspidosperma-scandine linkage, melosuavines D F (4-6), possessing an aspidosperma-aspidosperma skeleton, and melosuavines G and H (7 and 8) of the aspidosperma-venalatonine type, tenuicausine (9), and melodinine J (10) were isolated from the twigs and leaves of Melodinus suaveolens. The structures of 1-8 were elucidated by extensive spectroscopic methods, and compounds 9 and 10 were identified by comparison with data in the literature. The relative configuration 9 was determined from the ROESY spectrum, and some NMR signals were reassigned. Compounds 1, 2, 4-6, 8, and 10 exhibited low micromolar cytotoxicity against one or more of five human cancer cell lines.