Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age
Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age
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DOI：
10.1093/ajcn/84.4.903
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发表时间：
2006-10-01
影响因子：
7.1
通讯作者：
Gold, Diane R.
中科院分区：
文献类型：
--
作者：
Litonjua, Augusto A.;Rifas-Shiman, Sheryl L.;Gold, Diane R.
背景资料：低摄入量的膳食抗氧化剂可能有助于增加哮喘和allergy.Objective：我们调查了孕妇总摄入量（食物+补充剂）的10个抗氧化营养素在怀孕期间与喘息和湿疹在2-y-old childhood.Design：主题是1290母子对正在进行的队列研究。母亲的饮食和补充剂的摄入量进行了评估，使用验证的食物频率问卷管理在第一和第二孕期。计算抗氧化营养素摄入量。每种营养素的平均值被认为是怀孕期间的暴露量。感兴趣的结果是任何喘息的孩子在生命的第一年或第二年，在这两年反复喘息，湿疹在第一年或第二year.Results：没有观察到任何抗氧化营养素和湿疹的母亲总摄入量之间的关联。在多变量logistic回归模型中，母亲维生素E总摄入量的最高四分位数与最低四分位数相比[比值比（OR）：0.70; 95%CI：0.48，1.03]和锌（OR：0.59; 95% CI：0.41，0.88）与2岁时的任何喘息呈负相关（维生素E和锌摄入量四分位数的趋势P值分别为0.06和0.01）。维生素E（OR：0.49; 95% CI：0.27，0.90）和锌（OR：0.49; 95% CI：0.27）治疗2岁时反复喘息的结果相似。0.87）（P的趋势= 0.05和0.06四分位数的摄入量的维生素E和锌，分别）。结论：我们的研究结果表明，较高的母亲总摄入量的抗氧化剂在怀孕期间可能会降低儿童早期喘息性疾病的风险。
Background: Low intakes of dietary antioxidants may contribute to increases in asthma and allergy.Objective: We investigated the association of maternal total intakes (foods + supplements) of 10 antioxidant nutrients during pregnancy with wheezing and eczema in 2-y-old children.Design: Subjects were 1290 mother-child pairs in an ongoing cohort study. Maternal dietary and supplement intakes were assessed by using a validated food-frequency questionnaire administered in the first and second trimesters. Antioxidant nutrient intakes were calculated. and the mean for each nutrient was considered to be the exposure during pregnancy. The outcomes of interest were any wheezing by the child during either the first or second year of life, recurrent wheezing in both years, and eczema in either the first or second year.Results: No association was observed between maternal total intake of any antioxidant nutrient and eczema. In multivariate logistic regression models, the highest quartile compared with the lowest quartile of maternal total intakes of vitamin E [odds ratio (OR): 0.70; 95% Cl: 0.48,1.03] and zinc (OR: 0.59; 95% Cl: 0.41, 0.88) was inversely associated with any wheezing at 2 y of age (P for trend = 0.06 and 0.01 over quartiles of intake for vitamin E and zinc, respectively). Similar results were obtained for recurrent wheezing at 2 y of age with vitamin E (OR: 0.49; 95% Cl: 0.27, 0.90) and zinc (OR: 0.49; 95% Cl: 0.27. 0.87) (P for trend = 0.05 and 0.06 over quartiles of intake for vitamin E and zinc, respectively).Conclusion: Our results suggest that higher maternal total intakes of antioxidants during pregnancy may decrease the risks for wheezing illnesses in early childhood.