Cerebellar climbing fibers encode expected reward size
Cerebellar climbing fibers encode expected reward size
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DOI：
10.7554/elife.46870
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发表时间：
2019-10-29
期刊：
影响因子：
7.7
通讯作者：
Joshua, Mati
中科院分区：
文献类型：
--
作者：
Larry, Noga;Yarkoni, Merav;Joshua, Mati
攀爬纤维输入到小脑，编码指导学习的错误信号。最近，越来越多的证据表明，小脑也参与了奖励的处理。为了研究奖赏事件是如何被编码的，我们记录了猴子在进行眼动任务时攀爬纤维的活动。在每次试验开始时，研究人员都会向猴子提示成功完成试验后将获得的奖励大小。当给猴子提示大奖励而不是小奖励时，攀爬纤维的活动增加了。奖励大小不会调节奖励传递或眼球运动时的活动。攀爬纤维和简单穗活动的比较表明运动和奖赏编码的相互作用不同。这些结果表明，攀爬纤维编码了预期的奖励大小，并表明小脑在联想学习中的一般作用超出了错误纠正。
Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction.