Risk factors for recurrence of postoperative trichiasis - Implications for trachoma blindness prevention
Risk factors for recurrence of postoperative trichiasis - Implications for trachoma blindness prevention
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DOI：
10.1001/archopht.122.4.511
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发表时间：
2004-04-01
影响因子：
--
通讯作者：
Dean, D
中科院分区：
文献类型：
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作者：
Zhang, H;Kandel, RP;Dean, D
背景：沙眼是世界范围内可预防性失明的主要原因。手术可以减轻沙眼倒睫（TT），致盲的后遗症沙眼，但复发率是high.Objective：探讨TT复发的危险因素。方法：我们进行了一项前瞻性的病例对照队列研究，在尼泊尔，包括TT患者谁正在接受双板睑板旋转手术和对照组有疤痕，但没有TT。对结膜进行沙眼分级，并通过内部和商业（Roche Amplicor; Roche Diagnostics Corp，Indianapolis，Ind）-聚合酶链反应拭子检测沙眼衣原体。结果：术后6个月TT复发率为11.1%（4例），12个月为25.0%（11例），而对照组无TT发生。值得注意的是，11例TT复发患者中有5例（45.5%）在基线时有衣原体感染（比值比，6.0; 95%置信区间，1.5-24.3; P= 0.01），8例（72.7%）在6个月时有衣原体感染（比值比，28; 95%置信区间，4.3-181.0; P = 0.01）。
Background: Trachoma is the leading worldwide cause of preventable blindness. Surgery can alleviate trachomatous trichiasis (TT), the blinding sequelae of trachoma, but recurrence rates are high.Objective: To investigate risk factors for TT recurrence.Methods: We conducted a prospective case-control cohort study in Nepal that included patients with TT who were undergoing bilamellar tarsal-rotation surgery and control subjects who have scarring but no TT. Conjunctivae were graded for trachoma and swabbed to detect Chlamydia trachomatis by in-house and commercial (Roche Amplicor; Roche Diagnostics Corp, Indianapolis, Ind)-polymerase chain reaction. Univariate and multivariate analyses were performed for associations with chlamydiae and other risk factors.Results: Postoperative TT recurrence rates were 11.1% (4 cases) at 6 months and 25.0% (11 cases) at 12 months while no controls developed TT. Significantly, 5 (45.5%) of 11 patients with TT recurrences at 12 months had chlamydial infection at baseline (odds ratio, 6.0; 95% confidence interval, 1.5-24.3; P=.01), 8 (72.7%) at 6 months (odds ratio, 28; 95% confidence interval, 4.3-181.0; P