Biomechanical, histological and ultrastructural analyses of laser micro- and nano-structured titanium implant after 6 months in rabbit
Biomechanical, histological and ultrastructural analyses of laser micro- and nano-structured titanium implant after 6 months in rabbit
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DOI：
10.1002/jbm.b.31814
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发表时间：
2011-05-01
影响因子：
3.4
通讯作者：
Thomsen, Peter
中科院分区：
文献类型：
--
作者：
Palmquist, Anders;Emanuelsson, Lena;Thomsen, Peter
短期的，实验研究的部分激光改性种植体与纳米尺度的表面形貌特征，最近显示了相当大的增加，在生物力学锚定骨。本研究的目的是评估生物力学和骨结合能力的部分激光修饰种植体相比，机械加工种植体后，愈合期为6个月的兔模型。结果显示，移除扭矩增加了170%。组织学和扫描电子显微镜显示两种种植体类型的骨整合，但也揭示了界面和骨中不同的骨折模式。透射电子显微镜和化学分析表明，矿化组织和激光改性植入物的纳米结构表面之间的聚结。两者合计，结果表明，纳米结构表面促进体内长期骨结合和界面强度。(C)2011 Wiley Periodicals，Inc. J Biomed Mater Res Part B：Appl Biomater 97 B：289- 298，2011.
Short-term, experimental studies of partly laser-modified implants with nano-scale surface topographical features have recently shown a considerable increase in the biomechanical anchorage to bone. The aim of this study is to evaluate the biomechanical and bone-bonding ability of partly laser-modified implants compared with machined implants after a healing period of 6 months in a rabbit model. The results showed a 170% increase in removal torque. Histology and scanning electron microscopy demonstrated osseointegration for both implant types, but also revealed a different fracture pattern at the interface and in the bone. Transmission electron microscopy and chemical analysis showed coalescence between mineralized tissue and the nano-structured surface of the laser modified implant. Taken together, the results indicate that nano-structured surfaces promote in vivo long-term bone bonding and interface strength. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 97B: 289-298,2011.