The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: Six polymorphisms tested separately and as haplotypes
The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: Six polymorphisms tested separately and as haplotypes
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DOI：
10.1016/s0006-3223(96)00248-x
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发表时间：
1997-02-15
影响因子：
10.6
通讯作者：
Kidd, KK
中科院分区：
文献类型：
--
作者：
Chang, FM;Ko, HC;Kidd, KK
多巴胺能系统与酒精中毒有关，但对五种多巴胺受体之一的多巴胺D2受体基因（DRD 2）的研究并没有给出与酒精中毒相关的一致图片。我们现在已经研究了多巴胺D4受体基因（DRD 4）使用六个多态性，无论是单独的和单倍型。三组酗酒者从台湾（泰雅族，阿美族和汉族）诊断为严重的酒精依赖使用DSM-III-R标准，以及非酗酒者匹配的性别，种族和地理来源，分型聚合酶链反应（PCR）和/或PCR-限制性片段长度多态性（RFLP）的所有六个多态性。在所有三个台湾群体中，六个标记中有三个是多态的。虽然酗酒的患病率是显着不同的，没有高度显着的关联，这个位点与酗酒的观察，在任何三个组的分析是否考虑基因型分布或等位基因频率在三个多态性标记单独考虑和作为单倍型。在这些数据中，也没有任何明显的模式与所研究的群体中非常不同的酗酒患病率存在协变或暗示存在关系。特别是因为强大的，多位点单倍型分析在任何人口样本中没有统计学意义，我们得出结论，在台湾人口中，DRD 4基因座与酒精中毒没有关联。(C)1997年生物精神病学学会。
The dopaminergic system has been implicated in alcoholism but studies at the dopamine D2 receptor gene (DRD2), one of the five dopamine receptors, have not given a consistent picture of an association with alcoholism. We have now studied the dopamine D4 receptor gene (DRD4) using six polymorphisms, both separately and as haplotypes. Three groups of alcoholics from Taiwan (Atayal, Ami, and Han) diagnosed as having severe alcohol dependence using DSM-III-R criteria, together with nonalcoholics matched for gender, ethnic group, and geographic origin, were typed by polymerase chain reaction (PCR) and/or PCR-restriction fragment length polymorphism (RFLP) for all six polymorphisms. Three out of six markers are polymorphic in all three Taiwanese populations. Although the prevalence rates of alcoholism are remarkably different, no highly significant association of this locus with alcoholism was observed in any of the three groups whether the analysis considered genotype distributions or allele frequencies at the three polymorphic markers considered individually and as haplotypes. Neither is there any obvious pattern in the data that covaries with or hints at a relationship with the very different prevalences of alcoholism in the groups studied. Especially because the powerful, multi-site haplotype analysis was not statistically significant in any of the population samples, we conclude that there is no association of the DRD4 locus with alcoholism in Taiwanese populations. (C) 1997 Society of Biological Psychiatry.