Hot melt extrusion paired fused deposition modeling 3D printing to develop hydroxypropyl cellulose based floating tablets of cinnarizine.
Hot melt extrusion paired fused deposition modeling 3D printing to develop hydroxypropyl cellulose based floating tablets of cinnarizine.
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DOI：
10.1016/j.carbpol.2020.116519
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发表时间：
2020-10
影响因子：
11.2
通讯作者：
Anh Q. Vo;Jiaxiang Zhang;Dinesh Nyavanandi;S. Bandari;M. Repka
中科院分区：
文献类型：
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作者：
Anh Q. Vo;Jiaxiang Zhang;Dinesh Nyavanandi;S. Bandari;M. Repka
三维打印可以作为制造个体化药物和复杂结构固体剂型的平台。本文将热熔挤压与3D打印相结合，开发出一种独特的胃保留剂型，以个性化治疗肉桂嗪或其他窄吸收窗口药物。通过结合两种聚合物，羟丙基纤维素和乙烯基吡咯烷酮醋酸乙烯共聚物，优化了挤出股的机械强度。单位剂量、漂浮力和释放轮廓由打印参数和对象设计控制。片剂在FaSSGF内立即漂浮，在12 h内漂浮力相对恒定，药物释放服从零级动力学，6 h ~≥12 h可控制药物释放。输入变量与单位剂量、漂浮力、溶出度具有良好的相关性（R < 0.95） （p< 0.05）。作者成功地提出并测试了一种新的个性化医疗制造范式，以满足个体患者的需求。
Three-dimensional printing could serve as a platform to fabricate individualized medicines and complex-structured solid dosage forms. Herein, hot melt extrusion was coupled with 3D printing to develop a unique gastro retentive dosage form to personalize treatment of cinnarizine or other narrow absorption window drugs. The mechanical strength of the extruded strands was optimized for printing by combining two polymers, hydroxypropyl cellulose and vinylpyrrolidone vinyl acetate copolymer. The unit dose, floating force, and release profile were controlled by the printing parameters and object design. The tablets floated immediately within the FaSSGF, and floating force was relatively constant up to 12 h. Drug release followed zero-order kinetics and could be controlled from 6 h to≥ 12 h. Input variables had a good correlation (R> 0.95) with unit dose, floating force, and dissolution profile (p< 0.05). Authors successfully proposed and tested a new paradigm of individualized medicine fabrication to meet individual patient needs.