Effects of FUT-175, a New Synthetic Protease Inhibitor on Endotoxin-Induced Disseminated Intravascular Coagulation in Rats
Effects of FUT-175, a New Synthetic Protease Inhibitor on Endotoxin-Induced Disseminated Intravascular Coagulation in Rats
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新型合成蛋白酶抑制剂 FUT-175 对内毒素诱导的大鼠弥散性血管内凝血的影响
DOI：
10.1159/000214825
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Kondo
中科院分区：
文献类型：
--
作者：
T. Yoshikawa;M. Murakami;Y. Furukawa;H. Kato;S. Takemura;M. Kondo
本文研究了新型合成蛋白酶抑制剂FUT-175（6-氨基-2-萘-4-胍-苯甲酸-二甲磺酸）对内毒素诱导大鼠实验性弥散性血管内凝血（DIC）的影响。实验采用100mg /kg剂量内毒素持续输注4小时诱导DIC。将FUT-175按0.001、0.01、0.1、1.0、10.0 mg/kg的剂量连续注入大鼠股静脉4 h，在给药的同时，对侧股静脉注射内毒素100 mg/kg/4 h。在纤维蛋白原和纤维蛋白降解产物、纤维蛋白原水平、凝血酶原时间、部分凝血活素时间、血小板计数和存在纤维蛋白血栓的肾小球数量等方面，FUT-175均对大鼠的DIC有保护作用。这些结果表明FUT-175降低了DIC引起的凝血参数变化的程度。
The effects of FUT-175 (6-amidino-2-naphthyl-4-guanidino benzoate-dimethanesulfonate), a new synthetic protease inhibitor, on endotoxin-induced experimental disseminated intravascular coagulation (DIC) were studied in rats. Experimental DIC was induced by a 4-hour sustained infusion of endotoxin at a dose of 100 mg/kg. The rats were infused continuously with FUT-175 at 0.001, 0.01, 0.1, 1.0 or 10.0 mg/kg into a femoral vein for 4 h. Simultaneously with the agent infusion, endotoxin (100 mg/kg/4 h) was administered into the contralateral femoral vein. A protective effect against DIC was noted in the rats treated with 0.01 or 0.1 mg/kg of FUT-175 in the following parameters: fibrinogen and fibrin degradation products, fibrinogen level, prothrombin time, partial thromboplastin time, platelet count and the number of renal glomeruli with fibrin thrombi. These results demonstrated that FUT-175 reduces the extent of changes of the coagulation parameters caused by DIC.