EEG effects of conventional and denicotinized cigarettes in a spaced smoking paradigm.
EEG effects of conventional and denicotinized cigarettes in a spaced smoking paradigm.
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间隔吸烟范式中传统香烟和脱烟碱香烟的脑电图效应。
DOI：
10.1016/s0278-2626(03)00205-7
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发表时间：
2003
影响因子：
2.5
通讯作者：
Moolchan,EricT
中科院分区：
文献类型：
--
作者：
Pickworth,WallaceB;O'Hare,ElizabethD;Fant,ReginaldV;Moolchan,EricT
虽然血浆尼古丁水平与吸烟行为之间有文献记载，但最近的研究表明，去尼古丁化的香烟可以减少对烟草的渴望和戒断症状。在一项受试者间隔吸烟研究中，对去尼古丁化香烟（含有焦油，但尼古丁含量极低）和传统香烟进行了比较。在六个疗程中，受试者（n=10）每30、60或240分钟（8、4或1支）抽一次去尼古丁香烟或传统香烟。通过与吸烟前收集的脑电图记录进行比较，推断出每次吸烟最后一支烟的脑电图影响。常规香烟增加了脑电图频谱边缘频率，降低了θ功率，增加了β1功率。脱烟碱香烟降低了频谱频率。两种香烟对脑电图的影响取决于吸烟的时间。结果表明，烟碱释放量、近期性和吸烟过程对脑电图有重要影响；烟草烟雾中的其他非尼古丁成分也可能对脑电图产生影响。
Although there is a documented association between plasma nicotine levels and smoking behavior, recent studies indicate that denicotinized cigarettes reduced craving and symptoms of tobacco withdrawal. Denicotinized cigarettes (that deliver tar but insignificant amounts of nicotine) and conventional cigarettes were compared in a within-subject spaced smoking study. In six sessions, subjects (n=10) smoked denicotinized cigarettes or conventional cigarettes every 30, 60 or 240min (8, 4 or 1 cigarette(s)). EEG effects of the last cigarette of each session were deduced by comparisons with EEG recordings collected before smoking. Conventional cigarettes increased spectral edge EEG frequency, decreased θ power and increased β1 power. Denicotinized cigarettes decreased spectral frequency. The EEG effects of both cigarettes depended upon the recentness of smoking. The results indicate that nicotine delivery, recentness and the process of smoking importantly influence the EEG; other, non-nicotine components of tobacco smoke may also exert EEG effects.