FK 506: a new therapeutic agent for severe recalcitrant psoriasis.
FK 506: a new therapeutic agent for severe recalcitrant psoriasis.
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DOI：
10.1001/archderm.1992.01680160065005
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发表时间：
1991-12
影响因子：
0.9
通讯作者：
K. Abu-Elmagd;D. V. Thiel;B. Jegasothy;Cheryl D. Ackerman;S. Todo;J. Fung;A. Thomson;T. Starzl
中科院分区：
文献类型：
--
作者：
K. Abu-Elmagd;D. V. Thiel;B. Jegasothy;Cheryl D. Ackerman;S. Todo;J. Fung;A. Thomson;T. Starzl
在12至18个月前，我们用FK 506治疗了3例常规治疗无效的重度银屑病患者和4例在接受FK 506治疗的肝移植或肝移植前患有非扩散性偶发性银屑病的患者。所有人的精神病都得到了戏剧性的解决。只要提供了全剂量治疗，这种疾病就能保持缓解。连续的皮肤活检显示炎性浸润迅速消失，而表皮变化的消退较慢。在12至18个月的观察期内，FK 506耐受性良好，仅出现轻微副作用。银屑病自身免疫病因学的环境证据是银屑病病变的显著缓解。这可以用环孢菌素实现。其用于本发明的用途受到肾毒性的限制。高血压和其他剂量相关的副作用。我们在这里推荐使用化学上不相关的药物。FK 506其还抑制T辅助淋巴细胞活化以及细胞因子的合成和表达。4.~
BETWEEN 12 and 18 months ago we treated three patients with FK S06 who had severe psoriasis that was refractory to conventionai therapy and four patients with w,despread incidental psonasis before undergoing hean or liver transplantation under FK 506. All had dramatic resolution of psonasis. which remaIned in remission as long as full-dose therapy was provided. Serial skin biopsies had a rapid disappearance of the inflammatory infiltrate and slower resolution 01 epidermal changes. FK 506 was well tolerated with onlv minor side effects during the 12 to 18 months of observation. Circumstantiai evidence for an autoimmune etiology of psoriasis is the striking remission of psonatic lesions. which can be achieved with cyclosporine. l l an immunosuppressive drug whose use for this pUJ'l)Ose has been limited by nephrotoxicity. hypenension. and other doserelated side effects. We repon here the use of the chemically unrelated drug. FK 506. which also inhibits T helper lymphocyte activation and the synthesis and expression of cytokines. 4.~