DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats
DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats
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DOI：
10.1093/gerona/53a.1.b19
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Holloszy, JO
中科院分区：
文献类型：
--
作者：
Han, DH;Hansen, PA;Holloszy, JO
本研究旨在探讨脱氢表雄酮(DHEA)对雄性大鼠随增龄积累体脂和胰岛素抵抗的保护作用。我们发现，在5个月龄到大约25个月龄期间补充0.3%的DHEA导致最终体重显著降低(DHEA，593+/-18g比对照组，668+/-12g，p<；0.02)，尽管食物摄入量没有减少。瘦体重不受脱氢表雄酮的影响，较低的体重是由于体内脂肪减少了约25%。在正常血糖、高胰岛素钳夹期间，DHEA组的葡萄糖处理率比静坐对照组高30%，这是因为DHEA组的胰岛素响应性更强，DHEA组在降低体脂含量和维持胰岛素响应性方面与自愿车轮跑步形式的运动一样有效。脱氢表雄酮对肌肉GLUT4含量无显著影响。一项初步实验提供的证据表明，与对照组相比，DHEA处理组和车轮跑动组的肌肉胰岛素信号(反映了磷脂酰肌醇3-激酶与胰岛素受体底物-1的CT结合)得到了增强。这些结果提供了证据，表明DHEA和运动一样，可以防止大鼠过多的脂肪积累和胰岛素抵抗的发展。
The purpose of this study,uas to determine whether administration of dehydroepiandrosterone (DHEA) protects male rats against the accumulation of body fat and development of insulin resistance with advancing age. We found that supplementation of the diet with 0.3% DHEA between the ages of 5 months and approximate to 25 months resulted iii a significantly lower final body weight (DHEA, 593 +/- 18 g vs control, 668 +/- 12 g, p < 0.02), despite no decrease in food intake. Lean body mass was unaffected by the DHEA, and the lower body weight was due to a approximate to 25% reduction in body fat. The rate of glucose disposal during a euglycemic, hyperinsulinemic clamp was 30% higher in the DHEA group than in the sedentary controls due to a greater insulin responsiveness, The DHEA administration was as effective in reducing body fat content and maintaining insulin responsiveness as exercise in the form of voluntary wheel running. The DHEA had no significant effect on muscle GLUT4 content. A preliminary experiment provided evidence suggesting that muscle insulin signaling, as reflected Ct binding of phosphatidylinositol 3-kinase to the insulin receptor substrate-1, was enhanced in the DHEA-treated and wheel running groups as compared to controls. These results provide evidence that DHEA, like exercise, protects against excess fat accumulation and development of insulin resistance in rats.