The Effect of Early Time-Restricted Eating vs. Later Time-Restricted Eating on Weight Loss and Metabolic Health: A Network Meta-Analysis of Randomized Controlled Trials.
The Effect of Early Time-Restricted Eating vs. Later Time-Restricted Eating on Weight Loss and Metabolic Health: A Network Meta-Analysis of Randomized Controlled Trials.
复制标题
早期限时饮食与后期限时饮食对减肥和代谢健康的影响：随机对照试验的网络荟萃分析。
DOI：
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发表时间：
2023
影响因子：
5.8
通讯作者：
Feng Liu
中科院分区：
文献类型：
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作者：
Juanhong Liu;Pan Yi;Feng Liu
目的
在TRE干预中选择早期或晚期的每日进食窗口（早期或晚期TRE）对减肥和代谢健康是否有不同的影响仍然存在争议。进行了一项网络荟萃分析，以评估早期和晚期TRE在肥胖或超重成人中的疗效。
方法
我们检索了PubMed、Embase、Web of Science和科克伦图书馆，以查找截至2022年10月16日发表的随机对照试验（RCT）。我们进行了一项网络荟萃分析，以评估早期和晚期TRE对体重和代谢参数（包括血糖代谢、血压和血脂）的疗效。
结果
本荟萃分析纳入了12项随机对照试验，共纳入730名肥胖或超重成人。与非TRE相比，早期TRE和晚期TRE均引起体重和胰岛素抵抗（HOMA-IR）中度降低。有趣的是，早期TRE在改善胰岛素抵抗方面比晚期TRE更有效（早期与晚期TRE：-0.44，95%CI，-0.86至-0.02; P < 0.05），而在体重减轻方面没有检测到显著差异（早期与晚期TRE：-0.31 kg; 95%CI，-1.15至0.53 kg; P > 0.05）。 此外，与非TRE相比，早期TRE而不是晚期TRE在血糖代谢和血压方面显示出显着的益处。早期和晚期TRE之间的空腹血糖、血压和血脂无显著差异。
结论
这项荟萃分析表明，人们可能会选择早期TRE，以获得更有效的体重管理和代谢益处。然而，需要进一步的大规模随机对照试验来验证我们的发现。
OBJECTIVE
It remains controversial on whether the choice of the daily eating window early or later in TRE intervention (early or later TRE) has different effects on weight loss and metabolic health. A network meta-analysis was performed to evaluate the efficacy between early and later TRE in adults with obesity or overweight.
METHODS
We searched PubMed, Embase, Web of Science, and Cochrane Library for randomized controlled trials (RCTs) published until Oct 16, 2022. We conducted a network meta-analysis to evaluate the efficacy of early and later TRE on body weight and metabolic parameters, including glycemic metabolism, blood pressure, and lipid profiles.
RESULTS
12 RCTs with 730 obese or overweight adults were included in this meta-analysis. Both early TRE and later TRE elicited moderate reductions in body weight and insulin resistance (HOMA-IR) when compared to non-TRE. Interestingly, early TRE showed more effectiveness than later TRE in improving insulin resistance (early vs. later TRE: -0.44, 95% CI, -0.86 to -0.02; P < 0.05), whereas no significant difference was detected in weight loss (early vs. later TRE: -0.31 kg; 95% CI, -1.15 to 0.53 kg; P >0 .05). In addition, early TRE rather than later TRE showed significant benefits in glycemic metabolism and blood pressure when compared to non-TRE. No significant differences between early and later TRE were observed for fasting blood glucose, blood pressure, and lipid profiles.
CONCLUSIONS
This meta-analysis suggests that people may choose early TRE for more effective weight management and metabolic benefits. Nevertheless, further large-scale RCTs are warranted to verify our findings.