Altered structure of autoantigens during apoptosis
Altered structure of autoantigens during apoptosis
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DOI：
10.1016/j.rdc.2004.04.012
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发表时间：
2004-08-01
影响因子：
2.3
通讯作者：
Rosen, A
中科院分区：
文献类型：
--
作者：
Hall, JC;Casciola-Rosen, L;Rosen, A
凋亡细胞表面的自身抗原的聚集和浓度，结合凋亡细胞的显著耐受诱导功能，已经将注意力集中在凋亡细胞执行和清除的异常上，作为系统性自身免疫的潜在易感性和起始因素。细胞死亡过程中发生的结构变化可能会影响自身抗原的免疫原性。本文讨论的修改，自身抗原在细胞死亡过程中进行，确定某些促免疫形式的凋亡，其中自身抗原结构经常修改，并审查通过这种结构变化可能导致启动自身免疫反应的机制。
The clustering and concentration of autoantigens at the surface of apoptotic cells, in combination with the striking tolerance-inducing function of apoptotic cells, have focused attention on abnormalities in apoptotic cell execution and clearance as potential susceptibility and initiating factors in systemic autoimmunity. Structural changes that occur during cell death may influence the immunogenicity of self antigens. This article discusses the modifications that autoantigens undergo during cell death, identifies certain proimmune forms of apoptotic death in which autoantigen structure is frequently modified, and reviews the mechanisms through which such structural changes might lead to initiation of an autoimmune response.