A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane
A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane
复制标题
DOI：
10.1002/ajim.10320
复制
发表时间：
2004-01-01
影响因子：
3.5
通讯作者：
Takeuchi, Y
中科院分区：
文献类型：
--
作者：
Ichihara, G;Li, WH;Takeuchi, Y
本研究的目的是评估主要暴露于1-溴丙烷（一种臭氧消耗溶剂的替代品）对健康的影响，并建立评估1-溴丙烷暴露的生物标志物。方法对1-溴丙烷厂的24名女工和13名男工进行访谈，采集其尿液和血液样本。测量参数包括工厂中的1-溴丙烷水平、个体暴露水平、尿中1-溴丙烷水平、酶活性和血清肌酸激酶（CK） M亚基浓度。结果暴露于I -溴丙烷的工人报告的常见症状是鼻、喉、眼刺激或不适和/或头痛。尿1-溴丙烷水平与个体暴露水平显著相关，但酶活性或CK-M亚基不相关。结论患者表现为粘膜刺激及中枢神经系统不良反应。在暴露于低于170 ppm浓度的工人中，没有提示神经损伤的严重慢性症状。尿中溴丙烷水平可能是暴露的一个很好的指标。
Background The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers for assessing I -bromopropane exposure.Methods Twenty-four female and 13 male workers of a 1-bromopropane-factory were interviewed, and their urine and blood samples were collected. Measured parameters included 1-bromopropane levels in the factory, as well as individual exposure levels, urinary 1-bromopropane levels, enzymatic activity and M subunit's concentration of serum creatine kinase (CK).Results Frequent symptoms reported by workers exposed to I -bromopropane were nose, throat, and eyes irritation or malaise and/or headache. Urinary 1-bromopropane levels correlated significantly with individual exposure levels, but enzymatic activity or CK-M subunit did not.Conclusions The symptoms suggested irritation of the mucous membrane and possible adverse effects on the central nervous system. There were no severe chronic symptoms suggestive of neurological damage in workers exposed to less than 170 ppm. Urinary I bromopropane level may be a good indicator of exposure.