Active conservation of noncoding sequences revealed by three-way species comparisons
Active conservation of noncoding sequences revealed by three-way species comparisons
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DOI：
10.1101/gr.142200
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发表时间：
2000-09-01
期刊：
影响因子：
7
通讯作者：
Frazer, KA
中科院分区：
文献类型：
--
作者：
Dubchak, I;Brudno, M;Frazer, KA
人类和小鼠基因组序列比较越来越多地用于寻找进化上保守的基因调控元件。大规模的人-小鼠 DNA 比较研究发现了许多保守的非编码序列，其中只有一小部分进行了功能研究。因此，仍然存在一个问题：这些非编码序列中的大多数是由于功能限制而保守的，还是由于缺乏分歧时间的结果。
Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.