Polysaccharide Colloids as Smart Vehicles in Cancer Therapy
Polysaccharide Colloids as Smart Vehicles in Cancer Therapy
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DOI：
10.2174/1381612821666150820100812
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Pozo, David
中科院分区：
文献类型：
--
作者：
Caro, Carlos;Pozo, David
癌症是全球发病率和死亡率的主要原因之一，每年约有1400万新发病例和约800万癌症相关死亡。预计这些数字在今后几年内还会增加。因此，开发更有效和更有针对性的治疗方法非常重要。多糖由于其有趣的特性而广泛用于生物医学和制药应用，并且可以用于生产用于药物递送的纳米载体，因为它们经常延长半衰期并改善化疗剂在血流中的稳定性，使其能够到达肿瘤组织。此外，通常预期基于多糖的纳米载体通过减少不期望的副作用和促进更有效的细胞摄取来增加治疗益处。在这里，我们强调了各种多糖作为纳米载体在癌症治疗中的应用，主要集中在体内应用，并以关键的方式描述了每个设计系统的主要优点。使用不同的多糖与金属纳米粒子相互作用，以开发新的纳米车辆用于癌症治疗也将被讨论。
Cancer disease is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and around 8 million cancer-related deaths yearly. Estimates expect to increase these figures over the next few years. Therefore, it is very important to develop more effective and targeted therapies. Polysaccharides are widely used for biomedical and pharmaceutical applications due to their interesting properties, and can be utilised in the production of nanovehicles for drug delivery, since they frequently extend the half-life and improve the stability of chemotherapeutic agents in bloodstream allowing them to reach the tumour tissue. Moreover, polysaccharide-based nanovehicles are generally expected to increase the therapeutic benefit by reducing the undesired side effects and promoting a more efficient cellular uptake. Here, we highlight the application of various polysaccharides as nanovehicles in cancer therapy, focusing mainly on in vivo applications and describing the main advantages of each designed system in a critical way. The use of different polysaccharides interacting with metal nanoparticles to develop new nanovehicles for cancer therapy will also be discussed.